Search Results
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… The Cancer Genetics and Comparative Genomics Branch seeks to identify and study genes that contribute to cancer susceptibility and … and somatic (body cell) mutations that contribute to cancer susceptibility syndromes and to the development of … Where applicable, we conduct pathway analysis of targeted genes.  Applies genomic technologies for molecular diagnosis …
15 Ways Genomics Influences Our World
Genomics is transforming how we study, diagnose and treat cancer.
… Genomics is transforming how we study, diagnose and treat cancer. … Did you know that we are increasingly able to detect cancers by testing just a blood sample? Or that we … that some cancers have mutations in the same group of genes, even though they may have started in completely …
News Release
Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas Network have found.
… into four distinct molecular subtypes researchers with The Cancer Genome Atlas (TCGA) Network have found. In the study, … researchers think about developing treatments for stomach cancer, also called gastric cancers or gastric … in a minority of gastric adenocarcinomas and that EBV genes are expressed in those tumors. However, this study …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… for defining the biological significance of ancestry-related genomic variation in African-Americans. … of CVD in AA. The specific goals of the study are: To examine the associations between common or ancestry-related DNA variants and CVD risk factors (e.g. hypertension) …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… of loops, like those of a shoelace. Just as you learned to tie your shoes by forming separate "bunny ear" loops of string, your DNA forms many of these loops to create "genetic neighborhoods" within each bunny ear loop. These neighborhoods bring distant genes and specific gene control switches into close …
Educational Resources
An oncogene is a mutated gene that contributes to the development of a cancer.
… An oncogene is a mutated gene that contributes to the development of a cancer. … Carcinogen, Mutagen, Cancer, Cell, Mutation, Tumor Suppressor Gene … An oncogene is a mutated gene that has the potential to cause cancer. Before an oncogene becomes mutated, it is called a …
Talking Glossary
El cáncer es una enfermedad en la que algunas células del cuerpo crecen fuera de control. Hay muchos tipos diferentes de cáncer, y cada uno comienza cuando una única célula adquiere un cambio genómico (o mutación) que le permite dividirse y multiplicarse sin control.
… del sol). En determinados casos, las mutaciones en los genes que provocan cáncer son hereditarias, y eso aumenta el …
Educational Resources
Gene amplification is an increase in the number of copies of a gene sequence.
… DNA Sequence, Cancer, PCR, Polymerase Chain Reaction, Laboratory Experiment … Gene amplification refers to an increase in the number of copies of a gene in a genome. Cancer cells, for example, sometimes produce multiple copies …
Educational Resources
A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
… BRCA1, BRCA2, Cancer, Oncogene, Cell, Gene, Mutation … A tumor suppressor gene encodes a protein that acts to regulate cell division, keeping it in check. When a tumor … cell division may occur. Such mutations may contribute to the development of a cancer. …
News Release
Investigators with The Cancer Genome Atlas have discovered genomic differences in head and neck cancers caused by infection with the human papillomavirus.
… Investigators with The Cancer Genome Atlas (TCGA) Research Network have discovered … virus in the United States, and the number of HPV-related head and neck cancers has been growing. Almost every … will acquire HPV at some point in their lives, according to the Centers for Disease Control and Prevention. …