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Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… within many of us today. People with ancestry outside of Sub-Saharan Africa have 1% to 3% Neanderthal-derived sequences in …
Fact Sheet
Participation in genomics research is essential for improving the health of everyone.
… occur at different frequencies across different human populations; some are rare and unique to specific families, while others are common and found across populations.  Genomes from distinct populations differ due to multiple factors, including who … used for research are from European ancestry, making many populations from across the globe inadequately represented in …
News Release
The U.S. National Institutes of Health (NIH) has long invested in basic genetics and genomics research, clinical trials, as well as translational medicine and social science studies, to advance our understanding of this widespread illness to help develop effective therapies.
… disease common among those whose ancestors come from sub-Saharan Africa, Mediterranean countries, India and the Middle …
News Release
Researchers explored patients', parents' and physicians' perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease.
… nations. Sickle cell disease, appears throughout sub-Saharan Africa, Mediterranean basin, Middle East and India, …
News Release
NIH Center for Research on Genomics and Global Health is participating in the H3Africa Consortium's effort to develop an African-specific genotyping array.
… comprehensive characterization of genomic diversity across sub-Saharan Africa. The study, which used data generated from 20 …
News Release
More research must be done to understand the interactions of ancient genes with modern environments.
… comprehensive characterization of genomic diversity across sub-Saharan Africa. The study, which used data generated from 20 …
Research at NHGRI
A list of publications led by or in collaboration with the Center for Research on Genomics and Global Health.
… Sun Q, Wang Y, Tan T; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group *; … profiling and circulating triglyceride concentrations in sub-Saharan African individuals. Sci Rep . 14(1):20834. 2024. [ … actionable secondary findings in 130 triads from sub-Saharan African families with non-syndromic orofacial …
Staff
Dr. Amy Bentley is a Staff Scientist with the NHGRI's Center for Research on Genomics and Global Health.
… to investigate complex diseases in the context of diverse populations and the accompanying spectrum of variation in … traits, particularly serum lipids, in African ancestry populations. She also focuses on the complex interplay … in order to support the inclusion of African ancestry populations in such efforts. Dr. Bentley is very motivated by …
Staff
Abdel Elkahloun is an associate investigator in NHGRI's Office of Scientific Core Facilities.
… Study Associated Type 2 Diabetes Susceptibility Loci in Sub Saharan Africans. Front Genet , 24;6:335. 2016. [ PubMed ] … ancestry and clinical decision making for global populations. Pharmacogenomics J, 14(3): 217-22. 2014. [ …
Fact Sheet
Genomic variation accounts for some of the differences among people, including important aspects of their health and susceptibility to diseases.
… that aims to account for genomic variation across human populations, thereby reducing biases that can come with the … sufficient knowledge about genomic variation in all human populations, bringing equity in the benefits of genomic … plants, animals and other organisms. Such diversity keeps populations healthy and is fundamental to natural selection, …