Search Results
News Release
It’s teatime and doctors, researchers and patients are at the table. They celebrate a decade of work and launch the first in-human gene therapy trial for children with a rare and devastating disease, GM1 gangliosidosis.
… from her mother and father. Though both parents are healthy, they each have a mutated GLB1 gene. With only one … the guts of a harmless virus and replacing them with a healthy gene that is programmed to make the missing enzyme. … was no longer a concern. This demonstrated to the U.S. Food and Drug Administration that they were ready to test the …
Research at NHGRI
CRGGH uses genomic tools to understand the pathobiology of metabolic disorders, including obesity, hypertension, diabetes, dyslipidemia, and kidney disease.
… forces such as pathogens, climate, and ancient food scarcity have shaped human genomes and how these genomic … and lipid biomarkers mediate the metabolically healthy obesity phenotype: A shotgun proteomics Study. …
News Release
The U.S. National Institutes of Health (NIH) has long invested in basic genetics and genomics research, clinical trials, as well as translational medicine and social science studies, to advance our understanding of this widespread illness to help develop effective therapies.
… Today, the U.S. Food and Drug Administration (FDA) approved two gene …
Clinical Research
This study explores how microbes, such as bacteria and fungi, contribute to a very common skin condition called Atopic Dermatitis, known as eczema.
… invite you or your child to join a research study of both healthy volunteers and patients with atopic dermatitis … on the timing and scheduling of your study visits. For Healthy Children Without Eczema : (Age-Matched Controls or … to travel to the NIH Clinical Center, Bethesda, Md. Healthy children without eczema or asthma or siblings of …
The Genomics Landscape
In the April 2024 issue of The Genomics Landscape, NHGRI Director Eric Green details how the Office of Genomic Data Science (OGDS) is becoming the epicenter for genomic data science at the institute, with numerous collaborations, projects and activities.
… produced in the body by breaking down food, drugs, or other materials—in people with and without …
Research Funding
Frequently Asked Questions for IGVF RFAs: RFA-HG-20-043, RFA-HG-20-044, RFA-HG-20-045, RFA-HG-20-046, RFA-HG-20-047
… are appropriate for the proposed study and justify these choices in their applications. For this RFA, can an applicant … study and should explain the rationale for their proposed choices. NHGRI is interested in predictive modeling …
News Release
Scientists are using an exciting gene editing tool called CRISPR/Cas9 to protect plants from harmful DNA viruses, strengthening the plant's protections.
… due to DNA plant viruses, can threaten international food security and cause significant economic losses. After … methods to improve crop yield, protect plants and preserve food security. This research has planted seeds for intriguing …
Staff
Dr. Nakamura is the co-chief of NHGRI's Scientific Review Branch.
… NHGRI, Dr. Nakamura worked at Life Technologies, Inc. and Food and Drug Administration's National Center for …
The Informed Consent Resource
Explore genomics-relevant considerations for informed consent and guidance on how to approach them.
… can be challenging: investigators should ensure that any choices participants can make are clearly described and … form does not allow participants to make conflicting choices or choices that will be difficult for researchers to interpret. … there must be a robust mechanism for tracking these choices. Some types of results to consider when developing …
News Release
An online Informed Consent Resource created in 2009 by NHGRI has been updated to keep pace with advances in genomics over the past several years