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Educational Resources
A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest.
… A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest. … Chromosome, Gene, Deoxyribonucleic Acid (DNA), Positional Cloning … map, as related to genomics, is a graphical representation of physical locations of landmarks or markers (such as genes, …
The Genomics Landscape
In the August 6, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about NHGRI's completion of the third phase of the ENCODE Project and how it reveals the most extensive catalog to date of candidate functional elements that may regulate the genes in the human and mouse genomes.
… Each news cycle brings reminders about the importance of science and its critical role in society, and NHGRI … remains more committed than ever to facilitating the use of genomics for addressing all threats to human health – … historical milestone for genomics: the 30th anniversary of the launch of the Human Genome Project in October 2020. To …
Educational Resources
A locus is the specific physical location of a gene or other DNA sequence on a chromosome, like a genetic street address.
… A locus is the specific physical location of a gene or other DNA sequence on a chromosome, like a genetic street address. … Locus, Allele, DNA Polymorphism, Gene, Chromosome … within a genome (such as a gene or another DNA segment of interest), somewhat like a street address. The plural of …
News Release
Researchers from the NHGRI-funded Impact of Genomic Variation on Function Consortium are exploring how genomic variation affects genome function.
… Researchers from the NHGRI-funded Impact of Genomic Variation on Function Consortium are exploring how … While most DNA letters are the same amongst everyone, just under 0.5% … the past two decades, researchers have identified hundreds of millions of these differences, known as genomic variants , …
Educational Resources
A marker is a DNA sequence with a known physical location on a chromosome. Markers can help link an inherited disease with the responsible genes.
… A marker is a DNA sequence with a known physical location on a chromosome. … Marker, DNA Sequence, Gene, Inheritance … referred to as a genomic marker or a genetic marker) is a DNA sequence, typically with a known location in a genome. … are used as signposts (or landmarks) in the construction of DNA and genome maps. Markers can also be used to track …
Educational Resources
A primer is a short, single-stranded DNA sequence used in the polymerase chain reaction (PCR) technique.
… A primer is a short, single-stranded DNA sequence used in the polymerase chain reaction (PCR) … Deoxyribonucleic Acid (DNA), Gene Amplification, Hybridization, Polymerase Chain … polymerase chain reaction (PCR). In the PCR method, a pair of primers hybridizes with the sample DNA and defines the …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals. Editing DNA can lead to changes in physical traits, like eye color, … editing technologies enable scientists to make changes to DNA, leading to changes in physical traits, like eye color, …
Educational Resources
Southern blotting is a laboratory technique used to detect a specific DNA sequence in a blood or tissue sample.
… is a laboratory technique used to detect a specific DNA sequence in a blood or tissue sample. … Deoxyribonucleic Acid (DNA), Electrophoresis, Northern Blot, Probe, Restriction … larger fragments. The DNA fragments are transferred out of the gel or matrix onto a solid membrane, which is then …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… by replacing it or disrupting it with an artificial piece of DNA. … Knocking out the activity of a gene provides valuable clues about what that gene … with mice. Consequently, observing the characteristics of knockout mice gives researchers information that can be …
Educational Resources
ACGT is an acronym for the four types of bases found in a DNA molecule: adenine (A), cytosine (C), guanine (G), and thymine (T).
… ACGT is an acronym for the four types of bases found in a DNA molecule: adenine (A), cytosine (C), guanine (G), and … Thymine, Cytosine, Base Pair, Gene, Deoxyribonucleic Acid (DNA), Ribosome … ACGT is an acronym for the four types of bases found in a DNA molecule: adenine (A), cytosine (C), …