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News Release
NHGRI researchers, collaborators at the University of California (UC) San Diego, UC Davis and the University of Pittsburgh School of Medicine lay out a new framework for comparing dog-to-human aging, one that uses epigenetics as a biological marker to better understand the aging process.
… between humans and domestic dogs provides an emerging model of aging. … the results obtained with humans. Dogs are a useful model for such comparisons because much of their environment, … translate the age-related physiology experienced by one organism (e.g., humans) to the age at which physiology in a …
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… researchers, the reasons for using zebrafish as their model organism of choice are as varied as the diseases they study. … For Dr. Brooks' research program, using the zebrafish as a model is both practical and eye-opening."The zebrafish …
Research Funding
The developmental Genotype-Tissue Expression initiative's goal is to catalog and analyze transcriptional profiles from a wide variety of tissues from the pediatric period, including neonates through adolescents, in a post-mortem setting.
… tissues throughout development, filling a gap in genomic databases across developmental stages. The Non-Human Primate …
The Genomics Landscape
In the April 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., highlights the Telomere-to-Telomere (T2T) consortium's publishing of a collection of papers that reported the first truly complete sequence of the human genome.
… about how genomic data may later be shared in databases can sometimes be an afterthought, making it … form and training materials, which could be used as a model by others in point-of-care settings when collecting …
Research at NHGRI
The Technology Transfer Office is responsible for transferring NHGRI technologies to the private sector and exchanging research materials with outside groups.
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… Human Genome Project sequenced the genomes of a number of model organisms that are commonly used as surrogates in … as ENCODE (Encyclopedia of DNA Elements) and modENCODE (model organism Encyclopedia of DNA Elements) have compared and …
News Release
A genetic mutation that triggers bladder cancer in dogs is identical to a mutation that is implicated in multiple human cancers.
… way that canines may come to our aid-as a powerful animal model for research into human cancer. … which is not inherited but rather arises during an organism's lifetime, alters the protein and causes cells to … cancers are similar, and dogs already have served as a model in cancer research. They were central to immune system …
News Release
Scientists are using an exciting gene editing tool called CRISPR/Cas9 to protect plants from harmful DNA viruses, strengthening the plant's protections.
… called Cas9) allows scientists to snip out segments of an organism's DNA and insert new ones. While using the system to … species was chosen because it is well understood as a model organism, and new findings can be easily applied to other …
The Genomics Landscape
In 2022, The Genomics Landscape spotlighted genomic data sharing each month in a series of entries. This page contains a collection of each of those entries.
… such as the database of Genotypes and Phenotypes (dbGaP), model organism databases (e.g., Mouse Genome Informatics and Xenbase ), and … in a cloud environment. By inverting the traditional model of downloading data, AnVIL eliminates the need for a … form and training materials, which could be used as a model by others in point-of-care settings when collecting …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… gene is turned on or off in the cells and tissues of an organism. Depending on the technique used, it is often … Biology Laboratory have well-established gene expression databases. …