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Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… Epigenomics is a field in which researchers chart the locations and understand the … associated with body overgrowth and increased risk of cancer; Prader-Willi syndrome, associated with poor muscle … changes can lead to uncontrolled growth, a hallmark of cancer, or to a failure of the immune system to destroy …
Educational Resources
A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
… the system that regulates cell division. … BRCA1, BRCA2, Cancer, Oncogene, Cell, Gene, Mutation … A tumor suppressor … a protein that acts to regulate cell division, keeping it in check. When a tumor suppressor gene is inactivated by a … Such mutations may contribute to the development of a cancer. … A tumor suppressor gene directs the production of a …
Educational Resources
A complex disease is caused by the interaction of multiple genes and environmental factors.
… of multiple genes and environmental factors. … Genes, Cancer, Heart Disease, Gene-environment Interactions … A complex disease (or condition), when discussed in the context of genetics, reflects a disorder that results … genetic diseases include heart disease, diabetes, and cancer. … A complex disease is caused by the interaction of …
Educational Resources
A mutagen is a chemical or physical phenomenon, such as ionizing radiation, that promotes errors in DNA replication.
… such as ionizing radiation, that promotes errors in DNA replication. … Mutagen, DNA Mutation, DNA Replication, Cancer … A mutagen is a chemical or physical agent capable of inducing changes in DNA called mutations. Examples of mutagens include tobacco …
Educational Resources
Gene amplification is an increase in the number of copies of a gene sequence.
… Gene Amplification … Gene amplification is an increase in the number of copies of a gene sequence. … DNA Sequence, Cancer, PCR, Polymerase Chain Reaction, Laboratory Experiment … an increase in the number of copies of a gene in a genome. Cancer cells, for example, sometimes produce multiple copies …
Educational Resources
Apoptosis is the process of programmed cell death.
… death. … Programmed Cell Death, Development, DNA Repair, Cancer, Tumor, Cell Division … Apoptosis is the process of … example, those between the fingers of a developing hand. In adults, apoptosis is used to rid the body of cells that … beyond repair. Apoptosis also plays a role in preventing cancer. If apoptosis is for some reason prevented, it can …
News Release
NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… Mjoseth … A key challenge health care providers face in treating prostate cancer is distinguishing the aggressive, potentially … way to identify a specific subgroup of prostate cancer tumors with a known treatment option," said Elaine …
Educational Resources
Gene therapy is an experimental technique for treating disease by altering the patient's genetic material.
… … Genetic Disease, Genetic Disorder, Gene Mutation, Cancer Treatment, Healthcare … Gene therapy is a technique … is broken, or by replacing a defective or missing gene in a patient’s cells with a healthy version of that gene. …
Event
NHGRI, National Institute of Environmental Health Sciences (NIEHS) and National Cancer Institute (NCI) will host a pre-application interactive webinar for the Multi-Omics for Health and Disease program funding opportunity announcements (FOAs): RFA-HG-22-008,
RFA-HG-22-009 and RFA-HG-22-010.
… during the webinar and are encouraged to email questions in advance to MultiOmicsProgram@mail.nih.gov . … Agenda … … of Environmental Health Sciences (NIEHS) and National Cancer Institute (NCI) will host a pre-application … of Environmental Health Sciences (NIEHS) and National Cancer Institute (NCI) will host a pre-application …
Staff
Dr. Bailey-Wilson is a scientist emeritus in NHGRI's Division of Intramural Research.
… environmental risk factors. Dr. Bailey-Wilson specializes in statistical genetics and genetic epidemiology and is especially interested in risk factors for lung cancer, prostate cancer, eye disorders, autism and oral clefts. Dr. …