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Fact Sheets
Data used to estimate the cost of sequencing the human genome over time since the Human Genome Project.
… For many years, the National Human Genome Research Institute (NHGRI) has tracked the costs associated with DNA sequencing performed at the sequencing centers funded by the … data from 2001 through October 2007 represent the costs of generating DNA sequence using Sanger-based chemistries and …
Research at NHGRI
The NIH Intramural Sequencing Center is a multi-disciplinary genomics facility that emphasizes the generation and analysis of DNA sequence.
… The NIH Intramural Sequencing Center (NISC) , established in 1997, is a … procedures. NISC's role within the National Human Genome Research Institute (NHGRI), and more broadly across NIH, aims … methods to analyze genomics data with applicability to clinical and basic science questions that were thought to be …
Clinical Research
FAQs for Autoinflammatory Diseases Study providers and researchers.
… above, or patients who are older than 1 month and who have evidence of autoinflammatory disease (such as persistently … on new genetic discoveries. We can search our database of clinical and genetic data to see if we have a match. We may … Ivona Aksentijevich if you would like to further discuss research opportunities. … FAQ for Providers and Researchers … …
Research Training
Institutional and individual funding from NHGRI to help scientists develop research and professional skills.
… to improve human health. The National Human Genome Research Institute (NHGRI) provides both institutional and … Institutes of Health has updated policies regarding clinical trials (CT): Clinical Trial Requirements for Grants and Contracts A wealth …
News Release
The Telomere-to-Telomere (T2T) Consortium has generated the first truly complete sequence of a human Y chromosome - the final human chromosome to be fully sequenced.
… fertility, including sperm production. … An international research team has generated the first truly complete sequence … sequence particularly difficult to complete. Assembling sequencing data is like trying to read a long book cut into … assembly methods, as well as knowledge gained from generating the first gapless sequences for the other 23 human …
News Release
NHGRI awards $6.7 million in new research grants to develop DNA sequencing technologies that are more sensitive, faster, cheaper and more accurate.
… is surely not alone in his astonishment. The field of DNA sequencing is full of ideas that are just crazy enough to … Division of Genome Sciences at the National Human Genome Research Institute (NHGRI). "If we can't see what's there … $6.7 million in new research grants to develop DNA sequencing technologies that are more sensitive, faster, …
Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… DNA sequencing determines the order of the four chemical building … blocks - called "bases" - that make up the DNA molecule. … Sequencing DNA means determining the order of the four … were developed with support from the National Human Genome Research Institute (NHGRI) Genome Technology Program and its …
News Release
NIH lost a key member of its broader genomics team when Robert Blakesley, Ph.D., director of the NISC sequencing group at NIH, retired on Dec. 31, 2015.
… Jeannine Mjoseth … Genomics research is a quintessential team science. Contributing to … 31 retirement of Robert Blakesley, Ph.D., director of the sequencing group at the NIH Intramural Sequencing Center … has attained an extraordinary 90 percent success rate in generating sequence data from DNA samples accepted for study. …
Clinical Research
The Protocol Service Center provides assistance in the development and administration of study protocols requiring NIH Institutional Review Board approval.
… The National Human Genome Research Institute (NHGRI) Protocol Service Center (PSC) … of resources for the investigator wishing to conduct clinical research. Services that the PSC can provide to … Research Privacy, Privacy Of Research Participants, Clinical Trials, Genetic Disorders, Return Of Results, …
Clinical Research
A Longitudinal Natural History Study of Children with Mitochondrial Disease (at the NIH Clinical Center).
… to define the relationship between infection, immunity and clinical decline in individuals with mitochondrial disease. … with mitochondrial disease can lead to worsening clinical symptoms, particularly neurologic symptoms.  … treatments in the future. At the NIH, we are interested in research. Although we do provide advice and care for people …