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Educational Resources
Fluorescence in situ hybridization (FISH) is a laboratory technique for detecting and locating a specific DNA sequence on a chromosome.
… laboratory technique for detecting and locating a specific DNA sequence on a chromosome. … Laboratory Experiment, DNA … sequence on a chromosome. In this technique, the full set of chromosomes from an individual is affixed to a glass slide and then exposed to a “probe”—a small piece of purified DNA tagged with a fluorescent dye. The …
Educational Resources
Electrophoresis is a laboratory technique used to separate DNA, RNA, or protein molecules based on their size and electrical charge.
… Electrophoresis is a laboratory technique used to separate DNA, RNA, or protein molecules based on their size and … move faster than larger molecules. To determine the size of the molecules in a sample, standards of known sizes are separated on the same gel and then …
Educational Resources
A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest.
… Physical Map … A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest. … Chromosome, Gene, …
Educational Resources
A locus is the specific physical location of a gene or other DNA sequence on a chromosome, like a genetic street address.
… Locus … A locus is the specific physical location of a gene or other DNA sequence on a chromosome, like a genetic street address. … within a genome (such as a gene or another DNA segment of interest), somewhat like a street address. The plural of …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals. … diseases that affect humans. They edit the genomes of animals, like mice and zebrafish, because animals have …
Educational Resources
A primer is a short, single-stranded DNA sequence used in the polymerase chain reaction (PCR) technique.
… Primer … A primer is a short, single-stranded DNA sequence used in the polymerase chain reaction (PCR) … polymerase chain reaction (PCR). In the PCR method, a pair of primers hybridizes with the sample DNA and defines the … that will be amplified, resulting in millions and millions of copies in a very short timeframe. Primers are also used in …
Educational Resources
A marker is a DNA sequence with a known physical location on a chromosome. Markers can help link an inherited disease with the responsible genes.
… Marker … A marker is a DNA sequence with a known physical location on a chromosome. … are used as signposts (or landmarks) in the construction of DNA and genome maps. Markers can also be used to track inheritance of traits or disease risk in families. … A marker is a DNA …
Educational Resources
Southern blotting is a laboratory technique used to detect a specific DNA sequence in a blood or tissue sample.
… is a laboratory technique used to detect a specific DNA sequence in a blood or tissue sample. … Deoxyribonucleic Acid (DNA), Electrophoresis, Northern Blot, Probe, Restriction … larger fragments. The DNA fragments are transferred out of the gel or matrix onto a solid membrane, which is then …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… by replacing it or disrupting it with an artificial piece of DNA. … Knocking out the activity of a gene provides valuable clues about what that gene …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
… in some cases, more comprehensively analyze and interpret DNA sequence information from cancer patients. They have … (NHGRI), and the National Cancer Institute, both part of the National Institutes of Health, in addition to other organizations. Investigators …