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News Release
NIH will award $38.5 million over five years to the Developmental Genotype-Tissue Expression (dGTEx) project, which aims to build a widely available resource of human developmental gene expression in a multitude of tissues for use in basic and clinical research.
… Rachael Zisk … The project will increase our understanding of how gene expression is regulated over time. … Eleven years ago, researchers at the National Institutes of Health (NIH) saw a gap in the availability of high-quality …
Educational Resources
Population genomics is the application of genomic technologies to understand populations of organisms.
… Population Genomics … Population genomics is the application of genomic technologies to understand populations of organisms. … Gene, Genome, Genetic Variation, Allele, Founder Effect, …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals. … diseases that affect humans. They edit the genomes of animals, like mice and zebrafish, because animals have … about 85 percent of their genes! By changing a single gene or multiple genes in a mouse, scientists can observe how …
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… The Cancer Genetics and Comparative Genomics Branch seeks to identify and study genes that … to cancer susceptibility syndromes and to the development of various aggressive cancers, including prostate, … with both population scientists and clinicians to define gene profiles that offer predictability in terms of cancer …
The Genomics Landscape
In the October 1, 2020 edition of The Genomics Landscape, Dr. Eric Green reflects on the last 30 years since the launch of the Human Genome Project.
… then a postdoctoral research fellow in the laboratory of genomics pioneer Maynard Olson at Washington University … a set of studies describing how DNA variation can alter gene expression. The group of papers, published in Science …
Fact Sheets
Genome-wide association studies involve scanning markers across the genomes of many people to find genetic variations associated with a particular disease​.
… studies involve scanning markers across the genomes of many people to find genetic variations associated with a … involves rapidly scanning markers across the complete sets of DNA, or genomes, of many people to find genetic variations … form of blindness is associated with variation in the gene for complement factor H, which produces a protein …
Fact Sheet
A variety of approaches target the blood stem cells to relieve or reduce your symptoms of sickle cell disease.
… Types of treatments A variety of approaches target the blood stem cells to reduce your symptoms of sickle cell disease.  Gene therapies use your own stem cells, while bone marrow …
The Genomics Landscape
In the July 2020 edition of The Genomics Landscape, NHGRI Director Eric Green recalls the White House event announcing the draft human genome sequence.
… Eric Green, M.D., Ph.D. … As is likely the case for many of your organizations, NHGRI and NIH are starting to bring … past few months, NHGRI staff will continue pursuing our genomics-driven mission, whether working remotely from home … one that covered about 99 percent of the genome's gene-containing regions and had an accuracy of 99.99 percent. …
Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
… Methylation … Methylation is a chemical modification of DNA and other molecules that may be retained as cells … make more cells. … Methylation is a chemical modification of DNA and other molecules that may be retained as cells … make more cells. When found in DNA, methylation can alter gene expression. In this process, chemical tags called methyl …
Educational Resources
A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest.
… Physical Map … A physical map of a chromosome or a genome that shows the physical locations … genes and other DNA sequences of interest. … Chromosome, Gene, Deoxyribonucleic Acid (DNA), Positional Cloning … A physical map, as related to genomics, is a graphical representation of physical locations …