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… Slides_Epigenetic effects and gene expression.pptx …
News Release
Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas Network have found.
… facilitates cell growth and division, and the increased expression of JAK2 may inappropriately activate cell growth. … PD-L2, which suppress immune responses; their increased expression may help tumors escape destruction by the immune … process of adding methyl groups to DNA, which reduces gene expression. Hypermethylation occurs when this mechanism …
Research at NHGRI
The Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch studies the genomic and social determinants of complex diseases.
… genomic and social determinants; their effects on gene expression; as well as their contribution to health … cardiovascular disease morbidity and mortality and on gene expression among disproportionately affected subpopulations. …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… modeling studies demonstrated that neuronal-targeted expression of NPC1 rescued neurodegenerative disease, … arrest and senescence, suggesting maintenance of SOX10 expression is important for melanoma progression. These … also evaluate the effects these gene mutants have on other tissue types. Together, these studies will increase …
Staff
Dr. Michael Erdos is an Associate Investigator in the Molecular Genetics Section of the Center for Precision Health Research.
… Network for Systematic Analysis of Pancreatic Islet RNA Expression (InsPIRE) consortium. In addition, he is a … of T2D. Dr. Erdos is the lead scientist in the FUSION tissue biopsy project which aims to investigate tissue … cell state and functional consequence are integrated with genotype and polygenic risk to investigate the functional …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… RNA molecules involved in the regulation of gene expression. When the AAV was inserted near Mir341 , the vector caused elevated expression of the gene, which the researchers believe … that vector did not insert where it would elevate the expression of nearby genes and it did not cause liver cancer. …
News Release
NIH-funded researchers completed the PanCancer Atlas from over 10,000 tumors representing 33 types of cancer.
… of data analyses, such as investigating gene and protein expression profiles, and associating them with clinical and … a result that adds to our understanding of how tumor tissue of origin influences a cancer's features and could … underlying genome and epigenome on gene and protein expression; and the interplay of tumor and immune cells. …
News Release
A new study offers insights into why some people's hair goes gray in response to a serious illness or chronic stress.
… that decreased levels of the MITF gene. Decreasing the expression of the MITF gene in the mutant mice increased the … interferon signature. The other mouse model had increased expression of the SOX10 gene, which regulates MITF activity …
Educational Resources
Recessive Traits and Alleles is a quality found in the relationship between two versions of a gene.
… the relationship between two versions of a gene. … Gene, Genotype, Inherited, Mutation, Phenotype, Allele, Dominant … …
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
…  Develops and maintains banks of normal and tumor tissue (consisting of both germline and tumor DNA) for a … using whole-exome and whole-genome sequencing approaches, expression profiling methodologies (such as RNA-seq), and … microarray core that performs association and expression studies. In summary, the scientists of the Cancer …