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Educational Resources
Cystic fibrosis is a hereditary disease characterized by faulty digestion, breathing problems, respiratory infections, and loss of salt in sweat.
… Cystic Fibrosis (CF) … Cystic fibrosis is a hereditary disease characterized by faulty digestion, breathing … infections, and loss of salt in sweat. … Hereditary Disease, Family Health History, Gene, CFTR … Cystic fibrosis … or 40s, or even longer. … Cystic fibrosis is a hereditary disease characterized by faulty digestion, breathing …
Educational Resources
Genetic epidemiology is a relatively new medical discipline that seeks to understand how genetic factors interact with the environment in the context of disease in populations.
… factors interact with the environment in the context of disease in populations. … Genetic Epidemiology, Healthcare, Medicine, Population Genetics, Genetic Disease … Genetic epidemiology is a field of science focused … factors influence human traits, such as human health and disease. In many cases, the interaction of genes with the …
News Release
A new study highlights how genomic mutations that cause mitochondrial disease may also compromise affected people's immune response.
… highlights how genomic mutations that cause mitochondrial disease may also compromise affected people's immune response. … Based on clinical data from patients … mitochondrial disease may also compromise affected people's immune response. … Mitochondrial disease, human immune …
NEWS RELEASE
Final outcomes from the most comprehensive analysis to-date of humans and their microbiomes definitively link microbes and microbial activities with health problems.
… phase two of the Human Microbiome Project suggests. Who’s there? Surveying the microbiome in humans The National Institutes of Health’s (NIH) Common Fund established the decade-long Human … yet know if a change in a microbial community leads to a disease or if a microbial community changes in response to …
News Release
20 papers published online in 2014 highlight research on DNA biorepositories and electronic medical records to better understand the genomics of disease.
… (EMRs) to better understand the underlying genomics of disease. Many of the studies point to new associations of … researchers hope to reach this goal by combining a patient's data and disease characteristics with his or her genomic … repositories have been genotyped - that is, the individual's genetic make-up has been determined. With that information …
Fact Sheet
Your mental and physical health are deeply connected. Mental health is important for your health and quality of life. 
… strong impact on your physical health. Because of this, it’s important to care for your mental and physical health as … and/or trusted friend. Write about how you feel about your disease and how it affects your life. Reflect on why you … clinical trial. Discuss it with your healthcare provider(s) and your support system. … … … Reflect on what kind of …
News Release
A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… the discovery of gene function and the identification of disease genes in humans, according to scientists at the … Shawn Burgess, Ph.D., a senior investigator with NHGRI's Translational and Functional Genomics Branch and head of … is one of the two essential components in the NHGRI team's high-throughput method. Modeled on a defense mechanism …
Genetic Disorders
Progeria is an extremely rare genetic disease of childhood characterized by dramatic, premature aging.
… Progeria is an extremely rare genetic disease of childhood characterized by dramatic, premature … a key role in stabilizing the inner membrane of the cell's nucleus. In laboratory tests involving cells taken from … That abnormal protein appears to destabilize the cell's nuclear membrane in a way that may be particularly harmful …
Staff
Dr. Dan Kastner is an NIH Distinguished Investigator in Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… Genetics Branch. Throughout his career at the NIH Dan’s research has focused on using genetic and genomic … informed our understanding of more common illnesses. Dan’s group also proposed the now widely accepted overarching concept of autoinflammatory disease to denote disorders of the evolutionarily ancient …
Health FAQ
Discuss these questions with your doctor or health care provider.
… Project welcomes your feedback about the sickle cell disease gene therapy resources. Please email your comments or … organ damage in the long term.  … Every person’s experience may be different. Studies show that people who … site). … You will be under the care of your clinical trial’s team and physicians for about two to three years. During …