Search Results
Research Funding
The Knockout Mouse Phenotyping Project (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome.
… Jacqueline K The Jackson Laboratory The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2) OD023222 Dickinson, Mary E …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… 2001, and is principally responsible for supervising The Knockout Mouse Project (KOMP). The goal of the KOMP program, expected … cells. He is now working to implement The Knockout Mouse Phenotyping Project (KOMP2). The goal of this program is to …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked … with mice. Consequently, observing the characteristics of knockout mice gives researchers information that can be used …
Educational Resources
A knockout typically refers to an organism that has been genetically engineered to lack one or more specific genes.
… Knockout … A knockout typically refers to an organism that has been … engineered to lack one or more specific genes. … Knockout Mouse, Genetic Engineering, Gene, Laboratory …
News Release
The Encyclopedia of DNA Elements (ENCODE) Project has created a detailed resource on the letters of life, DNA, identifying genes and regions that may regulate genes in the human and mouse genomes.
… Prabarna Ganguly, Ph.D. … ENCODE Project's third phase offers new insights into the … millions of candidate DNA “switches” from the human and mouse genomes that appear to regulate when and where genes … tag. Animation depicting DNA “switches” from the human and mouse genomes that appear to regulate when and where genes …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
… Mouse Model … A mouse model is a laboratory mouse used to study some aspect of human physiology or disease. … Mouse Model, Knockout Mouse, Genetic Engineering, Laboratory Experiment, …
Event
The National Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International Mouse Phenotyping Consortium (IMPC)'s annual meeting at the Rockville Hilton in Rockville, Maryland, on November 19, 2019.
… Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International Mouse …
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… powerful clues to why certain processes and systems in the mouse - such as the immune system, metabolism and stress … so different from those in people. Building on years of mouse and gene regulation studies, they have developed a … The latest research results are from the mouse ENCODE project, which is part of the ENCODE, or ENCyclopedia Of DNA …
Educational Resources
A phenotype is an individual's observable traits, such as height, eye color, and blood type.
News Release
NIH and Inova Health are launching The Genomic Ascertainment Cohort, a pilot project that will examine gene and gene variant influence on phenotypes.
… Jeannine Mjoseth … Databases such as the 1000 Genomes Project and the Exome Aggregation Consortium (ExAC) harbor … The Genomic Ascertainment Cohort (TGAC), a two-year pilot project that will allow them to recall genotyped people and … exclusively to clinical investigation, with unparalleled phenotyping resources and capabilities. Most of the …