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News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… loop. These neighborhoods bring distant genes and specific gene control switches into close proximity. Genetic … merge in brain tumor cells. Researchers found that one gene came under the control of a gene control switch from a different genetic neighborhood, …
News Release
NIH researchers identified gene variants that cause a rare syndrome of sporadic fevers, skin rashes and recurring strokes, beginning early in childhood.
… National Institutes of Health researchers have identified gene variants that cause a rare syndrome of sporadic fevers, … that identified an overlapping set of variants of the same gene in patients with a similar type of blood vessel … The researchers found that harmful variants in the CECR1 gene impede production of a protein vital to the integrity of …
Educational Resources
Gregor Mendel was an Austrian monk who in the 19th century worked out the basic laws of inheritance, even before the term "gene" had been coined.
… out the basic laws of inheritance, even before the term "gene" had been coined. … Gregor Mendel, Genes, Human … out the basic laws of inheritance, even before the term "gene" had been coined. … Educational Resources …
Fact Sheets
Genomics is the study of all of a person's genes (the genome), including interactions of those genes with each other and with the person's environment.
… the information needed to build the entire human body. A gene traditionally refers to the unit of DNA that carries the … Specifically, an enzyme copies the information in a gene's DNA into a molecule called messenger ribonucleic acid … of all the bases in a large piece of DNA such as a gene, researchers need to read the sequence of overlapping …
Educational Resources
LOD stands for "logarithm of the odds." In genetics, the LOD score is a statistical estimate of whether two genes, or a gene and a disease gene, are likely to be located near each other on a chromosome.
… score is a statistical estimate of whether two genes, or a gene and a disease gene, are likely to be located near each other on a … probability that two loci (e.g., a disease-associated gene and another sequence of interest, such as a variant or …
News Release
When it comes to Attention-Deficit/Hyperactivity Disorder (ADHD), genetics do make an impact.
… unlike some illnesses, which are determined by a single gene, ADHD is not easily pinned down. Many common but subtle …
News Release
CMG investigators have made significant inroads in discovering genes underlying Mendelian conditions and have uncovered 470 new, previously unknown conditions.
… inherited, and typically caused by a mutation in a single gene. So far, researchers have identified the genomic causes … the program's progress and the breadth of Mendelian gene discovery to date. The authors also ruminated on the … disease. "Knowing that there is a relationship between a gene and a disease has enabled us to probe the development …
News Release
The Encyclopedia of DNA Elements (ENCODE) Project has created a detailed resource on the letters of life, DNA, identifying genes and regions that may regulate genes in the human and mouse genomes.
… to identify and characterize their functional roles in gene regulation. "A key challenge in ENCODE is that … to turn genes on or off, or tune the exact levels of gene activity, help drive the formation of distinct cell … has benefited from and built upon decades of research on gene regulation performed by independent researchers around …
Talking Glossary
LOH (short for “loss of heterozygosity”) refers to a type of mutation that results in the loss of one copy of a segment of DNA (typically containing a gene or group of genes).
… of one copy of a segment of DNA (typically containing a gene or group of genes). … LOH (short for “loss of … of one copy of a segment of DNA (typically containing a gene or group of genes). For most parts of the genome, human … of one copy of a segment of DNA (typically containing a gene or group of genes). … Talking Glossary …
Educational Resources
Antisense is the non-coding DNA strand of a gene.
… Antisense … Antisense is the non-coding DNA strand of a gene. … Non-coding DNA, Messenger RNA, Protein Synthesis … Antisense is the non-coding DNA strand of a gene. In a cell, antisense DNA serves as the template for … a protein. … Antisense is the non-coding DNA strand of a gene. … Educational Resources …