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Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… large-scale analysis of all the proteins in an organism, tissue type, or cell (called the proteome). Proteomics can be … blastocyst have the ability to develop into every type of tissue (skin, liver, kidney, blood, etc.) found in an adult … patient's immune system may react and reject the donated tissue as "foreign." However, by using stem cells, there may …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… out in an ES cell, the effects can be observed in any tissue in an adult mouse. In addition, ES cells grown in the …
The Genomics Landscape
In the July 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., emphasizes the importance of the Technology Transfer Office and its mission to manage all the legal negotiations that help to protect federally funded research from being unduly exploited, while also giving that research avenues to reach patients through the commercialization of promising advances.
… Genes for Non-Insulin Dependent Diabetes Mellitus - Tissue Biopsy Study” is a long-term, international, and …
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… researchers found that differences appeared in specific tissue and cell types. "We didn't know before these results … sites (which identify regulatory DNA) in 45 mouse cell and tissue types to those in humans. They reported in Science … his colleagues compared gene expression in 15 different tissue types in mice and humans. Contrary to previous …
News Release
The skin microbiota plays an intricate role in the human immune system, directing many immune functions and defending against bacterial pathogens.
… to an immune-system receptor. S. epidermidis also inhibits tissue colonization by the highly pathogenic S. aureus , the … Among these functions are overall immune system screening, tissue repair, wound healing, inflammation control, … If S. epidermidis fails to confine S. aureus to the nasal tissue that it often inhabits, the human host could be in for …
News Release
A repurposed cancer drug appears to reduce the severity of lesions and pain experienced by people with Proteus syndrome
… the researchers looked at was the cerebriform connective tissue nevus (CCTN), which is a disfiguring, massive …
Staff
Dr. Alexander Arguello is a program director in the NHGRI Division of Genome Sciences.
… Reference Program (HGRP) and Developmental Genotype-Tissue Expression (dGTEx) initiatives as well as the …
The Informed Consent Resource
Explore the basic elements of informed consent that are required by the Common Rule and that are relevant to genomics.
… name of previous project or biobank]. Your blood and tissue samples contain DNA, which makes up the genes that … The process for the collection of samples (blood or other tissue) and health information. Whether researchers will have … If your doctors collected a blood sample (or other tissue sample) as part of your medical care, we will study …
Staff
Dr. Michael Erdos is an Associate Investigator in the Molecular Genetics Section of the Center for Precision Health Research.
… of T2D. Dr. Erdos is the lead scientist in the FUSION tissue biopsy project which aims to investigate tissue specific effects of T2D associated variants on the … Dr. Erdos has been collecting pancreatic islets and liver tissue from cadaveric tissue distribution organizations in …
The Genomics Landscape
In June 1, 2023, edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., talks about the NHGRI-funded Human Pangenome Reference Consortium releasing a high-quality collection of human genome reference sequences, which together comprise a human “pangenome” reference.
… to establish the SMaHT Network through grant awards for a Tissue Procurement Center, five Genome Characterization …