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News Release
NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.
… of Health researchers have identified a novel role for a gene known as heat shock protein 60 ( Hsp60 ), finding that … "This study proposes an unusual role for a well-known gene," said Shawn Burgess, Ph.D., head of NHGRI's … today in the journal npj Regenerative Medicine . "This gene is found in every organism from bacteria to man. We have …
Fact Sheet
Early in the COVID-19 pandemic, researchers used state-of-the-art genomic sequencers to quickly sequence the SARS-CoV-2 virus.
… genomic sequencers to quickly sequence the SARS-CoV-2 virus. This sequence was quickly shared with other … allowed researchers from across the globe to analyze the virus and better understand how it causes disease. The speed … bioinformatics approaches, they selected the spike protein gene as their vaccine candidate. The spike protein is …
Policy Issues
Most ethical discussions about genome editing center on human germline editing because changes are passed down to future generations.
… attempted at this time, but that studies that would make gene therapy  safe and effective should continue. 1 , 2  Most … in December 2015 with the International Summit on Human Gene Editing  in Washington, DC. For more information on this …
News Release
NIH will award nearly $80 million to support the establishment of the Mendelian Genomics Research Consortium and the development of novel methods and approaches that help researchers identify the genetic causes of single-gene diseases.
… help researchers identify the genetic causes of single-gene diseases. Over 400 million people worldwide have been … generally thought to be caused by mutations in a single gene. The awards will be provided by the National Human … research community to perform more robust Mendelian gene discovery projects. The new clinical centers will be led …
Talking Glossary
Un retrovirus es un virus que utiliza ARN como material genómico.
… Retrovirus … Un retrovirus es un virus que utiliza ARN como material genómico. … A retrovirus is a virus that uses RNA as its genomic material. Upon infection … which infect other cells. Many retroviruses are associated with diseases, including AIDS and some forms of …
Educational Resources
A genotype is an individual's collection of genes.
… BB, Bb, bb could be used to represent a given variant in a gene. Genotypes can also be represented by the actual DNA …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… targets. Although excitement about the potential for gene therapy has grown tremendously since the discovery of CRISPR, … variants in these "controlling" regions of the genome are associated with disease risk. In the case of common diseases, …
Educational Resources
A promoter is a sequence of DNA needed to turn a gene on or off.
… Promoter … A promoter is a sequence of DNA needed to turn a gene on or off. … Deoxyribonucleic Acid (DNA), Enzyme, Gene, Gene Expression, Gene Regulation, Messenger RNA (mRNA), …
News Release
NIH will award $38.5 million over five years to the Developmental Genotype-Tissue Expression (dGTEx) project, which aims to build a widely available resource of human developmental gene expression in a multitude of tissues for use in basic and clinical research.
… Zisk … The project will increase our understanding of how gene expression is regulated over time. … Eleven years ago, … of high-quality tissue samples and information on gene expression — important resources that scientists needed … It also established a resource for researchers to explore gene expression in many different tissues to understand the …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… a rational approach to drug discovery and personalizing therapy. Oregon Health and Science University (OHSU), … on cellular phenotypes, protein make-up and gene expression readouts in cell lines. Broad Institute of … genes. Each perturbation will produce about 1,000 gene-expression readouts. By the project's end, Dr. Golub …