Search Results
Research Funding
ClinGen will advance genomics in clinical care and improve our understanding of phenotypic and functional effects of genetic variants and their clinical value.
… efforts in the establishment of standards in the use of ancestry and diversity information in clinical genomics and … could be prevented or mitigated if the risk were known Ancestry and Diversity Alice Popejoy Carlos Bustamante Investigate how ancestry information is used in clinical genomics and provide …
News Release
A new phase of the IGNITE Network will conduct clinical trials of genomic medicine interventions.
… three conditions are more common among people of African ancestry than European and Asian descent. Specific African … to diverse clinical care settings. “Patients of African ancestry might experience better management of high blood …
Health
A polygenic risk score is one way by which people can learn what their risk of developing a disease is, based on the total number of genomics variants related to the disease.
… studies to date have examined individuals of European ancestry. Because of this issue, there may not be adequate … beyond polygenic risk scores. The percentage  of ancestry populations included in large-scale genomic studies … risk scores may only be valid and useful for European ancestry populations. More research is needed to derive the …
Research Funding
The three research domains to be considered for support by the NHGRI Ethical, Legal and Social Implications Research Program.
… social inequities. How concepts of race, ethnicity and ancestry have been (and are currently) used in genomic … genomics on the conceptualization of race, ethnicity and ancestry across diverse individuals and groups. How genomic … direct-to-consumer (DTC) companies that offer genetic ancestry testing and other genomic services, law enforcement, …
News Release
NIH-led study finds genetic markers that explain up to 12% of the differences between two people’s blood pressure.
… the collected data was mostly from people of European ancestry (due to limited availability of diverse datasets … risk scores were also applicable to people of African ancestry, which was confirmed through analyzing data from …
News Release
The National Academy of Medicine elected Dr. Charles Rotimi, CRGGH Director, as one of its new members.
… For groundbreaking research in African and African ancestry populations, providing new insights into the genetic …
Healthcare Provider Genomics Education Resource
An FAQ designed to help healthcare professionals understand the diverse landscape of direct-to-consumer (DTC) genetic testing and the benefits and limitations of these tests.
… information about their genetic information (generally ancestry, some health traits and health risks) from a saliva … the support of a qualified healthcare professional.  For ancestry results, DTC-GT may reveal a genetic relationship to … do not cover all ethnic populations equally; therefore ancestry results for underrepresented minority populations …
Genetic Disorders
Thalassemia is a group of inherited diseases of the blood that affect a person's ability to produce hemoglobin, resulting in anemia.
… Italian, Greek, Middle Eastern, Southern Asian and African Ancestry. The two main types of thalassemia are called … individuals of Southeast Asian, Chinese and Filipino ancestry, results in fetal or newborn death. A child who …
Research Training
The FLAGSHIP program aims to train early career postdoctoral scientists to become future leaders in genomic sciences research.
Staff
Dr. Guanjie Chen is a senior research fellow with the NHGRI's Center for Research on Genomics and Global Health.
… AP, Chen G, et al. Variation in APOL1 Contributes to Ancestry Level Differences in HDLc-Kidney Function … associated with boday mass index in individuals of African ancestry. Nat Genet: 2013 Jun.; 45(6):690-696: PMID:23583978 … wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet: …