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News Release
The TCGA network describes uterine and bile duct cancer.
… uncontrolled cell growth that is the hallmark of malignant tumors. Last month, two publications from the TCGA network …
News Release
Researchers from The Cancer Genome Atlas Research Network identify novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma.
… identified, clinicians may be able to treat patients whose tumors have specific gene changes with drugs currently …
Genetic Disorders
Attention Deficit Hyperactivity Disorder (ADHD) is a neurological disorder that affects a person's ability to control their behavior and pay attention to tasks.
… are: 1) familial: ADHD often runs in families; 2) abnormal brain development; or 3) brain injuries occuring before, during or after birth. … Brain images of children with ADHD may show differences …
Staff
Dr. Philip Shaw is an investigator in the Social and Behavioral Research Branch at the National Human Genome Research Institute.
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… environmental factors that influence the development of brain and behavior. A focus of his work is the most common … factors in shaping the developmental trajectories of brain and behavior. The program focuses on one of the most … to behavioral processes that can be mapped directly onto brain structure and function. The work linking brain …
Staff
Dr. Sudre is an Associate Investigator in Dr. Philip Shaw's Neurobehavioral Clinical Research within the Social and Behavioral Research Branch
… at Carnegie Mellon University investigating how the human brain represents information. More specifically, they looked for semantic information in the brain while subjects perform several cognitive tasks and used … with machine learning techniques to classify different brain states. Previously, Dr. Sudre was part of the Human …
For Patients and Families
​Pharmacogenomics combines the science of how drugs work, called pharmacology, with the science of the human genome, called genomics.​
… (Herceptin). This therapy works only for women whose tumors have a particular genetic profile that leads to … (Tarceva), work much better in lung cancer patients whose tumors have a certain genetic change. On the other hand, … very well in the 40 percent of colon cancer patients whose tumors have a particular genetic change. Pharmacogenomics may …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… codes for a protein that normally suppresses the growth of tumors by arresting cell division. Humans born with mutations … with more than half of human cancers and often lead to tumors in a particular set of tissues. However, when the p53 gene is knocked out in mice, the animals develop tumors in a different array of tissues.Despite these …
News Release
When Dr. Ellen Sidransky, 2019 winner of the Jay Van Andel Award, looks into a rare disease, she finds a window to take the lead in Parkinson's research.
… General Hospital. She was looking at diseases of the brain. "I'm doing an autopsy on a patient with Parkinson's … Would you like me to send you a sample from this brain?" Sidransky recalls her saying. Because Gaucher disease is very rare, having a brain sample of an inflicted person was a real opportunity. …
Staff
Abdel Elkahloun is an associate investigator in NHGRI's Office of Scientific Core Facilities.
… University of Michigan for the study of sarcomas and solid tumors and then joined the National Human Genome Research … of the Hippocampal Transcriptome Following Mild Traumatic Brain Injury After Controlled Cortical Impact in the Rat. J …
News Release
A genetic mutation that triggers bladder cancer in dogs is identical to a mutation that is implicated in multiple human cancers.
… BRAF -targeted therapy strategies," they added. Canine tumors carrying the mutation also offer a new environment for … high frequency of the mutation, examination of the dog tumors might enable us to determine why this particular …