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News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher … of the disease. Using this model, they have now tested a drug compound that has successfully corrected the … patients with Parkinson's disease." … Testing Potential Drug Therapies … Related Content … NIH researchers use a new …
News Release
NIH grants aim to gauge if genomics can be used to help diagnose diabetes, manage heart disease and guide cancer clinicians to the most effective drugs.
… keep heart disease patients out of hospitals and guide cancer clinicians and patients to the most effective drugs. … … which studies how a patient's genetic make-up affects drug responses. A third grant examines the role of genomic … on genomically guided prescriptions of cardiovascular and cancer drugs. David Flockhart, M.D. , Ph.D. , Indiana …
The Genomics Landscape
In the June 2018 issue of The Genomics Landscape, NHGRI Director Eric Green highlights the success of The Cancer Genome Atlas.
… the field of genomics.  …  After more than a decade, The Cancer Genome Atlas (TCGA) program is drawing to an end. A … initiated and supported by NHGRI and the National Cancer Institute (NCI), with over $300 million in total … mission to catalog the genomic changes underlying multiple cancer types. Ambitious in scope from the beginning, TCGA was …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… switch from a different genetic neighborhood, turning on a cancer-growth gene. The research team was led by Bradley E. … in energy production, seemed to have no relevance to cancer. Dr. Bernstein and his colleagues found that when the … this hypothesis by adding 5-Azacytidine, a chemotherapy drug that disrupts formation of methyl tags, to glioma cells. …
Research Funding
Effort to accelerate understanding of the molecular basis of cancer using genome analysis technologies, including large-scale genome sequencing.
… The Cancer Genome Atlas (TCGA) was a joint effort of the National Cancer Institute (NCI) and the National Human Genome Research … alterations in head and neck cancers, new potential drug targets  (2015)  TCGA study improves understanding of …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… She conducted her postdoctoral training at Fox Chase Cancer Center, Philadelphia, before joining Harvard Medical … on the fine-mapping of genomic deletions in ovarian cancer and in malignant mesothelioma as a means to home in on … to lung cancer may be associated with the T790M drug resistance mutation in EGFR . Nat Genet, 37:1315-1316. …
Jobs at NHGRI
Postdoctoral positions are available in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the National Human Genome Research Institute, at NIH.
… in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the … to research into the molecular underpinnings of uterine cancer. The overarching goal of the laboratory is to identify … of the most clinically aggressive forms of endometrial cancer. Our research entails the functional annotation of …
Jobs at NHGRI
Postdoctoral positions are available in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the National Human Genome Research Institute, at NIH.
… in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the … to research into the molecular underpinnings of uterine cancer. The overarching goal of the laboratory is to identify … of the most clinically aggressive forms of endometrial cancer. Our research entails the functional annotation of …
Educational Resources
A carcinogen is an agent with the capacity to cause cancer in humans.
… … A carcinogen is an agent with the capacity to cause cancer in humans. … Cancer, Tumor, Genetic Mutation, Chemical … A carcinogen is a substance, organism or agent capable of causing cancer. Carcinogens may occur naturally in the environment …
Staff
Elaine Ostrander is chief of NHGRI's Cancer Genetics and Comparative Genomics Branch.
… is Chief and Distinguished Senior Investigator of the Cancer Genetics and Comparative Genomics Branch at the … Dr. Ostrander joined the faculty of the Fred Hutchinson Cancer Research Center and University of Washington in 1993, … state-of-the-art genomic approaches to identify prostate cancer susceptibility genes in both high-risk families and …