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Research Funding
MorPhiC aims to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene by using in-vitro multicellular systems.
News Release
Researchers used whole genome sequence data to investigate the origin of the mutation that causes "sickling" of red blood cells.
… of the sickle allele will help clinicians redefine sickle cell subgroups and treat patients more effectively. This … "sickling" of red blood cells. … Sickle allele, Sickle cell disease, Center for Research on Genomics and Global …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell. It can trigger the assembly of new molecules, such as a fat or protein, turn genes on and off, or spur a cell to move. … For your body to develop properly and stay …
News Release
NIH investigators have discovered that genomic switches of a blood cell are key to regulating the human immune system.
… (NIH) have discovered the genomic switches of a blood cell are key to regulating the human immune system. The … micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Source: … important for the function and identity of each individual cell type. In addition, a large number of disease-associated …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… Cellular Signatures (LINCS). Discovering such cell responses will improve scientists' understanding of cell pathways and aid in the development of new therapies for … Dr. Jaffe's LINCS Center for Proteomic Characterization of Signaling and Epigenetics will study cell disruption at the …
News Release
Researchers are trying to understand a process whose rules are constantly being written and rewritten by cancer's rogue cells: who will more likely relapse.
… better understand what mutations - changes to the cancer cell's DNA - may lead to relapse. In recent research … A genome can be thought of as a huge DNA "book" in each cell that includes all of our genes (the chapters), and … significant differences between the genome of a healthy cell and that of a cancer cell. The analysis of the cancer …
News Release
NHGRI published its “Strategic vision for improving human health at The Forefront of Genomics” in the journal Nature. This vision describes the most compelling research priorities and opportunities in human genomics for the coming decade, signaling a new era in genomics for the Institute and the field.
… and opportunities in human genomics for the coming decade, signaling a new era in genomics for the Institute and the … and opportunities in human genomics for the coming decade, signaling a new era in genomics for the Institute and the … and opportunities in human genomics for the coming decade, signaling a new era in genomics for the Institute and the …
Fact Sheet
Understanding gene therapy for sickle cell disease
… Sickle cell disease is the most common inherited blood disorder in … are only a handful of options to manage or treat sickle cell disease. Now, researchers are developing new and emerging gene therapies to treat sickle cell disease. To help navigate these new therapies, more than …
Talking Glossary
Mosaicism refers to the presence of cells in a person that have a different genome from the body’s other cells.
… later in development. Mosaicism can affect any type of cell and does not always cause disease. … Mosaicism refers to …
News Release
The U.S. National Institutes of Health (NIH) has long invested in basic genetics and genomics research, clinical trials, as well as translational medicine and social science studies, to advance our understanding of this widespread illness to help develop effective therapies.
… approved two gene therapies for the treatment of sickle cell disease in patients 12 years and older. About 100,000 … and millions of people around the world have sickle cell disease , a hereditary disease common among those whose … technology is critical to the diagnosis of sickle cell disease. NIH researchers successfully edited the …