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News Release
National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study may inform the development of treatments for hearing loss in humans.
… shows the role of transcription factors in facilitating cell regeneration …  Brightfield image of a two-day-old … the potential for researchers to understand the biology of cell regeneration in zebrafish before translating the … learning, Jimenez and her collaborators found that hair cell regeneration in zebrafish relied on a network of …
Staff
Dr. Edward Giniger is an adjunct investigator in NHGRI's Genetics and Molecular Biology Branch.
… of fruit flies, a model system that allows biochemical and cell biological approaches to be merged with classical and … on the surface of fly nerve cells, called Notch, engages signaling proteins inside the axon that make it grow or turn … in Drosophila photoreceptor neurons. Mol Biol of the Cell, 25:2993-3005. 2014. [ PubMed ] Smith-Trunova, S., …
Educational Resources
A lymphocyte is a type of white blood cell that is part of the immune system.
… Lymphocyte … A lymphocyte is a type of white blood cell that is part of the immune system. … Lymphocytes, White Blood Cell, Immune System … A lymphocyte is a type of white blood cell that is part of the immune system. There are two main …
Educational Resources
Prostate cancer is a disease characterized by uncontrolled cell growth in the prostate gland, which is part of the male reproductive system.
… Prostate cancer is a disease characterized by uncontrolled cell growth in the prostate gland, which is part of the male reproductive system. … Cancer, Cell, Mitosis, Mutation … Prostate cancer is a disease characterized by uncontrolled cell growth in the prostate gland, which is part of the male …
Educational Resources
A bacterial artificial chromosome (BAC) is an engineered DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli).
Talking Glossary
Aneuploidy is an abnormality in the number of chromosomes in a cell due to loss or duplication. In humans, aneuploidy would be any number of chromosomes other than the usual 46.
… is an abnormality in the number of chromosomes in a cell due to loss or duplication. In humans, aneuploidy would … is an abnormality in the number of chromosomes in a cell due to loss or duplication. In humans, aneuploidy would … is an abnormality in the number of chromosomes in a cell due to loss or duplication. In humans, aneuploidy would …
News Release
NIH is launching a program, Molecular Phenotypes of Null Alleles in Cells (MorPhiC), to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene.
… function and behave differently depending on the type of cell in which they are expressed. In addition, genes may turn on or off depending on the cell’s relationship to surrounding cells, environment and age. Research funded by the MorPhiC program will use cell culture models such as organoids, which are miniature, …
News Release
NIH researchers researchers and collaborators have gained some key insights into the biological inner-workings of regrowing a body, the evolution of aging and a unique method to dispose of aging cells, by studying the genomes of a hermit crab (Hydractinia symbiolongicarpus).
… known as senescence. According to the study published in Cell Reports , Hydractinia demonstrates that the fundamental …
Event
Pre-application webinar on for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) data analysis validation centers funding opportunity announcement (FOA) on September 7, 2022.
Staff
Dr. Settara Chandrasekharappa is an associate investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… receptor, was found to be responsible for AGS. The Notch signaling pathway, originally discovered in fruit flies, is important in determining early cell-fate decisions. The Chandrasekharappa lab participated … activation of Notch signaling by Delta. Developmental Cell , 4:67-8. 2003. [ PubMed ] Rodriguez, V., Chen, Y., …