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Educational Resources
A complex disease is caused by the interaction of multiple genes and environmental factors.
… of complex genetic diseases include heart disease, diabetes, and cancer. … A complex disease is caused by the …
Talking Glossary
Una enfermedad (o afección) compleja, cuando se analiza en el contexto de la genética, refleja un trastorno que se produce por las contribuciones de múltiples variantes genómicas y genes además de influencias considerables del entorno fÃsico y social.
… of complex genetic diseases include heart disease, diabetes, and cancer. … Una enfermedad (o afección) compleja, …
News Release
A genetic mutation that triggers bladder cancer in dogs is identical to a mutation that is implicated in multiple human cancers.
Research at NHGRI
CRGGH facilitates understanding of the relationship between genetic variation and population differences in disease distribution to inform health disparities.
… of metabolic disorders, including obesity, hypertension, diabetes, dyslipidemia, and kidney diseases, in different …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… such as height and susceptibility to common diseases like diabetes and heart disease usually stem from a complicated …
Staff
Dr. Guanjie Chen is a senior research fellow with the NHGRI's Center for Research on Genomics and Global Health.
… with Obesity in West Africans and African Americans. Diabetes 2010 Jun. PMID: 20299471 Meilleur KG, Doumatey A, … proliferative diabetic retinopathy in patients with Type 1 diabetes. Ophthalmic Res. 2011;46. PMID: 21088442 Charles BA, … provides insight into the genetic architecture of Type 2 diabetes. PLos Genetic 2014, 10(8), PMID:25102180 Yuan A, …
Research Funding
Polygenic RIsk MEthods in Diverse populations (PRIMED) Consortium will work together to develop and implement approaches to integrating extant genotype and phenotype data for the purpose of conducting and disseminating Consortium-wide PRS analyses.
… Ng, Alisa Manning Development of Polygenic Risk Scores for Diabetes and Complications Across the Life-Span in …
File
… Families Share Disease Worksheet: What is Type 2 Diabetes? …
Staff
Jie Zhou is a data manager and SAS programmer at NHGRI's Center for Research on Genomics and Global Health.
… with obesity in West Africans and African Americans. Diabetes. 2010 Jun;59(6):1549-54. doi: 10.2337/db09- 1252. … C. Genome-wide search for susceptibility genes to type 2 diabetes in West Africans: potential role of C-peptide. Diabetes Res Clin Pract. 2007 Dec;78(3):e1-6. Epub 2007 Jun …
Staff
Dr. Charles Rotimi is the scientific director of and NIH Distinguished Investigator in the Division of Intramural Research. He also serves as the director of the Center for Research on Genomics and Global Health (CRGGH).
… and blood pressure in African Americans and for type-2 diabetes in West Africans. His lab contributes to the global … on populations of African ancestry. The Africa America Diabetes Mellitus (AADM) study, developed under Dr. Rotimi's … has enrolled over 6,500 related and unrelated type-2 diabetes (T2D) cases and ethnically matched controls from …