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Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… genetic contributions from either parent, they found that expression in 95 genes in the brain depended more on being … of genes in the brain, there was a slightly greater expression of genes inherited from the father than from the … ARTICLE: Crowley, et al . Analyses of allele-specific gene expression in highly divergent mouse crosses identifies …
Staff
Dr. Wilson is the co-chief of and senior investigator in NHGRI's Computational and Statistical Genomics Branch.
… that may be responsible for phenotypic variation in quantitative traits (e.g., traits related to cardiovascular … and non-coding elements that may be responsible for their expression, and the investigation of the statistical … RM. Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects: application …
Staff
Dr. Charles Rotimi is the scientific director of and NIH Distinguished Investigator in the Division of Intramural Research. He also serves as the director of the Center for Research on Genomics and Global Health (CRGGH).
… with more than 2 million markers, and (3) whole genome expression analysis on skeletal muscle obtained from biopsy … Comuzzie AG, Lowe WL, Luke A, Blangero J, Cooper RS. The quantitative trait locus on chromosome 2 for serum leptin levels is …
Research at NHGRI
NHGRI researchers develop freely available software and analysis tools to help researchers around the world analyze and explore their genomic data.
… genetic association studies. ROMPrev A software suite for quantitative trait and locus-specific heritability estimation and association …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… modeling studies demonstrated that neuronal-targeted expression of NPC1 rescued neurodegenerative disease, … Dr. Pavan’s group has collaborated to identify expression quantitative trait loci (eQTL) in a large cohort of primary melanocytes, …
Research at NHGRI
CRGGH uses genomic tools to understand the pathobiology of metabolic disorders, including obesity, hypertension, diabetes, dyslipidemia, and kidney disease.
… and excretion (ADME) of pharmaceutical drugs. Gene expression RT-PCR for genes of interest using Applied … chemistry on BIO-RAD instruments (MyiQ). Whole genome gene expression array, such as the GeneChip® Human genome U133 … regression model to evaluate the association between the trait and variants in that region. The program executable and …
Staff
Dr. Francis Collins is a senior investigator in Center for Precision Health Research.
… part in several worldwide GWAS consortia studying T2D and quantitative traits. To date, these consortia have identified … DNA methylation (by bisulfite sequencing), gene expression (by RNA-seq), and phenotypes on more than 300 … M, Saulino A, Letcher R, Wigler M, Collins FS. The NF1 locus encodes a protein functionally related to mammalian GAP …
The Genomics Landscape
In the November 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, celebrates the 30th anniversary of the NHGRI Intramural Research Program as well as announces the launch of a new digital history archive.
… changes in cis and trans and the evolution of gene expression in humans and chimpanzees Barr et al. Genome Biol … transcription factors — proteins that regulate the expression of genes — that function differently between the …
Staff
Dr. Heidi Parker is an Associate Investigator in the Comparative Genetics Section of the Cancer Genetics and Comparative Genomics Branch, NHGRI.
… This led to the discovery of the first cancer associated locus found through population-based analyses in the dog. She … architecture, canine breed structure, simple and complex trait mapping and genomic analysis of canine tumors. The … JA, Davis BW, Knapp DW, and Ostrander EA. RNAseq expression patterns of canine invasive urothelial carcinoma …
Staff
Dr. Guanjie Chen is a senior research fellow with the NHGRI's Center for Research on Genomics and Global Health.
… G, Ramos E, Adeyemo A, Shriner D. et al. UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur … G. Dunston, F. Collins, C. Rotimi. A Genome Wide Scan for quantitative trait loci linked to obesity phenotypes among West Africans. …