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News Release
NIH researchers have created a data resource show how differences in an individual's genome can affect gene activity and contribute to disease.
… Expression (GTEx) project have created a new and much-anticipated data resource to help establish how … in the DNA code - control how, when and how much genes are turned on and off in different tissues, and can … individuals in order to understand the causal effects of genes and variants, and which tissues contribute to …
Educational Resources
In genomic imprinting the ability of a gene to be expressed depends upon the sex of the parent who passed on the gene.
… passed on the gene. … Genetic Imprinting, DNA Sequence, Genes, Family Health History, Genealogy, Gene Expression … … genomic mutations that can affect the ability of inherited genes to be expressed, genomic imprinting does not affect the … egg or sperm formation. Epigenetic tags on imprinted genes usually stay in place for the life of the individual. … …
News Release
NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.
… ), finding that it is critical in tissue regeneration and wound healing. The study found that topical treatment of … Institute (NHGRI), the National Eye Institute (NEI), and their colleagues, may help in the development of … in diabetic patients, as well as for normal wound healing and scar reduction. "This study proposes an unusual role for …
Fact Sheet
A variety of approaches target the blood stem cells to relieve or reduce your symptoms of sickle cell disease.
… , your stem cells are changed by altering part of your genes. Types of gene therapy include gene addition and gene editing . There are two types of gene editing: gene … are present at the time of the gene therapy nor alter the genes that you pass on to your children. … Bone marrow …
News Release
NIH will award nearly $80 million to support the establishment of the Mendelian Genomics Research Consortium and the development of novel methods and approaches that help researchers identify the genetic causes of single-gene diseases.
… Genomics Research Consortium will include five centers and a data coordination site. … The National Institutes of … have been identifying about 300 Mendelian disease genes each year using a technique called whole-exome … sequencing has not been successful in identifying the genes responsible for many Mendelian diseases, requiring new …
Educational Resources
A genotype is an individual's collection of genes.
… Genotype … A genotype is an individual's collection of genes. … Genotype, Genes, DNA Sequence, Phenotype … A genotype is a scoring of … at a specific location, such as CC, CT, TT. DNA sequencing and other methods can be used to determine the genotypes at …
Educational Resources
A promoter is a sequence of DNA needed to turn a gene on or off.
… of a gene where relevant proteins (such as RNA polymerase and transcription factors) bind to initiate transcription of …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… Genetics and genomics both play roles in health and disease. Genetics refers to the study of genes and the way that certain traits or conditions are … another. Genomics describes the study of all of a person's genes (the genome). … Genetics is a term that refers to the …
News Release
NIH will award $38.5 million over five years to the Developmental Genotype-Tissue Expression (dGTEx) project, which aims to build a widely available resource of human developmental gene expression in a multitude of tissues for use in basic and clinical research.
… a gap in the availability of high-quality tissue samples and information on gene expression — important resources that … scientists needed to understand how differences in our genes directly affect the makeup and function of our bodies. … “We hope this project will lend more insight into how our genes are expressed at each stage in our lives.” Multiple …
News Release
NHGRI researchers have discovered clues to the possible cause of recurring, non-contagious fevers and sores that affect only children. Several genes have been implicated with the syndrome, known as PFAPA syndrome (Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis), which could lead to new treatments.
… Ph.D. … Study shows mutations in inflammation-related genes are associated with PFAPA syndrome … Researchers at the … to the possible cause of recurring, non-contagious fevers and sores that affect only children. Several genes have been implicated with the syndrome, known as PFAPA …