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Educational Resources
Cancer is a group of diseases characterized by uncontrolled cell growth.
… Cancer … Cancer is a group of diseases characterized by … a genomic change (or mutation) that allows the cell to divide and multiply unchecked. Additional mutations can … ultraviolet rays). In certain cases, mutations in cancer genes are inherited, which increases a person’s risk of …
News Release
Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas Network have found.
… as has been done in the past, researchers will now be able to explore therapies in defined sets of patients whose tumors … Stomach cancers are a leading cause of cancer-related mortality worldwide, resulting in an estimated … in a minority of gastric adenocarcinomas and that EBV genes are expressed in those tumors. However, this study …
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… The Cancer Genetics and Comparative Genomics Branch seeks to identify and study genes that contribute to cancer susceptibility and … the use of mouse and other small animal models for cancer-related genetic and functional studies.  Supports national …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… for defining the biological significance of ancestry-related genomic variation in African-Americans. … … of CVD in AA. The specific goals of the study are: To examine the associations between common or … by improving our knowledge of the relationship between genes, social factors, the environment and cardiovascular …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… of loops, like those of a shoelace. Just as you learned to tie your shoes by forming separate "bunny ear" loops of … each bunny ear loop. These neighborhoods bring distant genes and specific gene control switches into close … [ Nature ] … Chemotherapy May Be A Useful Treatment … Related Content … The "bunny ear" hypothesis: How defective …
Talking Glossary
El cáncer es una enfermedad en la que algunas células del cuerpo crecen fuera de control. Hay muchos tipos diferentes de cáncer, y cada uno comienza cuando una única célula adquiere un cambio genómico (o mutación) que le permite dividirse y multiplicarse sin control.
… que le permite dividirse y multiplicarse sin control. … Cancer is a disease in which some of the body’s cells grow … a genomic change (or mutation) that allows the cell to divide and multiply unchecked. Additional mutations can … ultraviolet rays). In certain cases, mutations in cancer genes are inherited, which increases a person’s risk of …
Educational Resources
An oncogene is a mutated gene that contributes to the development of a cancer.
… Oncogene … An oncogene is a mutated gene that contributes to the development of a cancer. … Carcinogen, Mutagen, Cancer, Cell, Mutation, Tumor … … An oncogene is a mutated gene that has the potential to cause cancer. Before an oncogene becomes mutated, it is …
Educational Resources
A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
… the system that regulates cell division. … BRCA1, BRCA2, Cancer, Oncogene, Cell, Gene, Mutation … A tumor suppressor gene encodes a protein that acts to regulate cell division, keeping it in check. When a tumor … cell division may occur. Such mutations may contribute to the development of a cancer. … A tumor suppressor gene …
Educational Resources
Gene amplification is an increase in the number of copies of a gene sequence.
… the number of copies of a gene sequence. … DNA Sequence, Cancer, PCR, Polymerase Chain Reaction, Laboratory Experiment … Gene amplification refers to an increase in the number of copies of a gene in a genome. … sometimes produce multiple copies of a gene(s) in response to signals from other cells or the environment. … Gene …
News Release
Investigators with The Cancer Genome Atlas have discovered genomic differences in head and neck cancers caused by infection with the human papillomavirus.
… virus in the United States, and the number of HPV-related head and neck cancers has been growing. Almost every … will acquire HPV at some point in their lives, according to the Centers for Disease Control and Prevention. … The … 70 percent of head and neck cancers had alterations in genes for growth factor receptors ( EGFR, FGFR, IGFR, MET, …