Search Results
Research Funding
MorPhiC aims to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene by using in-vitro multicellular systems.
… Expired Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase I: Data Analysis and Validation Centers … November 2, 2022 Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Production Research and … November 2, 2021 Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Analysis and Validation Centers …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… work together at many different levels - from organs to cells to genes. From both inside and outside the body, cells are constantly receiving chemical cues prompted by such … or lack of food. To react and adjust to these cues, cells send and receive signals through biological pathways. …
News Release
Researchers used whole genome sequence data to investigate the origin of the mutation that causes "sickling" of red blood cells.
… origin of the mutation that causes sickling of red blood cells, which reduces their ability to carry oxygen and can … origin of the mutation that causes "sickling" of red blood cells. ​ … Sickle allele, Sickle cell disease, Center for … origin of the mutation that causes "sickling" of red blood cells. … News Release …
News Release
NIH investigators have discovered that genomic switches of a blood cell are key to regulating the human immune system.
… occur when the immune system mistakenly attacks its own cells, causing inflammation. Different tissues are affected … Dr. O'Shea's team began by searching for SEs in T cells, immune cells known to play an important role in rheumatoid …
Genetic Disorders
Klinefelter syndrome is a condition that occurs in men as a result of an extra X chromosome. The most common symptom is infertility.
… being the XY/XXY mosaic. In this variation, some of the cells in the male's body have an additional X chromosome, and … risk for breast cancer, a rare tumor called extragonadal germ cell tumor, lung disease, varicose veins and … Infertility, Gynecomastia, Breast Cancer, Extragonadal Germ Cell Tumor, Lung Disease, Varicose Veins, Osteoporosis, …
News Release
Researchers are trying to understand a process whose rules are constantly being written and rewritten by cancer's rogue cells: who will more likely relapse.
… being written and rewritten by the cancer's rogue cells. Untangling the genetic influences on these rules will … analyses. This allowed the team to study the cancer cells' genome. A genome can be thought of as a huge DNA … (the chapters), and provides all the instructions for our cells to do their jobs. Because cancer cells have many …
Fact Sheet
Understanding gene therapy for sickle cell disease
Talking Glossary
Mosaicism refers to the presence of cells in a person that have a different genome from the body’s other cells.
… Mosaicism … Mosaicism refers to the presence of cells in a person that have a different genome from the body’s other cells. … Mosaicism refers to the presence of cells in a person that have a different genome from the …
News Release
The U.S. National Institutes of Health (NIH) has long invested in basic genetics and genomics research, clinical trials, as well as translational medicine and social science studies, to advance our understanding of this widespread illness to help develop effective therapies.
… edited the disease-causing mutation in blood-forming cells taken directly from people with sickle-cell disease. …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… and genetic factors - that are potentially disruptive to cells. LINCS researchers then will measure the cells' tiniest molecular and biochemical responses, and use … common patterns, as well as uncommon behavior, in how cells respond to being exposed to various small molecules, …