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Genetic Disorders
Colon cancer is a malignant tumor of the large intestine that affects both men and women.
… higher than in the average person. These hereditary cancers typically occur at an earlier age than sporadic … discovered that leads to FAP: the APC gene, located on human chromosome 5. However, over 300 different mutations … risk of developing colon or rectal cancer. However, these cancers account for only three to five percent of all …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
… doctor may take a "wait and watch approach" to these early cancers, and follow the man with regular PSA blood tests and …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… Ph.D., and Shawn Burgess, Ph.D., both of the National Human Genome Research Institute (NHGRI), and their colleagues … its genome has close counterparts to about 70 percent of human genes. Another feature makes the zebrafish especially … primordium" (PLLp) mimics the behavior of metastasizing human cancer. The cluster of zebrafish neural cells - which …
News Release
Receiving a cancer diagnosis can feel like losing control of everything.
… and Functional Genomics Branch at the National Human Genome Research Institute (NHGRI). "In a way, it's like … outcomes for different tumor types. For example, in breast cancers, CIMP is associated with a lower risk of malignant … and Laura Elnitski. Pan-cancer stratification of solid human epithelial tumors and cancer cell lines reveals …
News Release
Researchers are trying to understand a process whose rules are constantly being written and rewritten by cancer's rogue cells: who will more likely relapse.
… and Functional Genomics Branch at the National Human Genome Research Institute, and their collaborators … cells follow certain rules outlined by genes, other cancers may relapse in much the same way. Identifying AML's …
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… cell endometrial cancer (CCEC) tumors to date, National Human Genome Research Institute (NHGRI) researchers and their … other types of uterine cancer, namely serous endometrial cancers or endometrioid endometrial cancers. The study was published May 9, 2017, in the journal …
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The Cancer Genome Atlas identified molecular subtypes to help clinicians determine which tumors are more aggressive and which will respond to treatment.
… more than 20,000 new PTC cases each year. Most thyroid cancers are slow-growing and treatable with surgery, hormone … managed by the National Cancer Institute and the National Human Genome Research Institute, both parts of the National … and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting …
News Release
How well cancer patients fare after chemotherapy can be affected by their social interaction with other patients during treatment.
… according to a new study by researchers at the National Human Genome Research Institute (NHGRI), part of the National …
News Release
Researchers from The Cancer Genome Atlas Research Network identify novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma.
… by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), both part of the … "Combined with the earlier TCGA analysis of squamous lung cancers, we now have a comprehensive understanding of many of … of Health, an agency of the Department of Health and Human Services. The NHGRI Division of Intramural Research …
News Release
A repurposed cancer drug appears to reduce the severity of lesions and pain experienced by people with Proteus syndrome
… determine the correct dose of the medicine. NIH's National Human Genome Research Institute (NHGRI) researchers and … the findings Feb. 21, 2019, in the American Journal of Human Genetics . … "We discovered that a much lower dose of … because the drug was originally developed for treating cancers that were activated by a variant of the gene AKT1 , …