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News Release
Researchers build a statistical model using family health history to improve disease risk assessment
Researchers at the National Human Genome Research Institute (NHGRI) have developed a new statistical model that can predict the risk for developing diseases by combining information about family member health and lifestyle factors from family members.
… models that can only be used for complex diseases such as hypertension, high cholesterol and heart disease. In …
Staff
Dr. Charles Rotimi is the scientific director of and NIH Distinguished Investigator in the Division of Intramural Research. He also serves as the director of the Center for Research on Genomics and Global Health (CRGGH).
… His team published the first genome-wide scan for hypertension and blood pressure in African Americans and for … and CARe for Renal Function ( PLoS Genet, 2011). Ongoing hypertension research activities in the branch include …
Event
On October 25-29, 2022, the National Human Genome Research Institute (NHGRI) will participate in the ASHG Annual Meeting - the world's largest human genetics and genomics meeting and exposition.
Diversity Center
Meharry Medical College establishes a Diversity Center for Genome Research (DCGR) that will narrow inequitable representation gaps for underrepresented, disadvantaged minority by realizing their vision to promote African ancestry genomic research through infrastructure building and the formation of basic, clinical, and computational science research teams that are inclusive, interdisciplinary, and community-engaged.
… diseases with known health disparities, such as cancer, hypertension, kidney disease, diabetes, obesity, …
Research Funding
The PAGE Consortium investigates ancestrally diverse populations to gain a better understanding of how genetic factors influence susceptibility to disease.
… traits (lipids, diabetes/obesity, CHD/ECG, cancer, hypertension/kidney, inflammation), SNP selection and quality …
Research Funding
The IGNITE PTN supports a network of multi-site clinical groups involving diverse settings and populations to conduct two pragmatic clinical trials of genomic medicine interventions.
News Release
Researchers have conducted the first study to look at the genomic underpinnings of obesity in continental Africans and African Americans.
… by increasing a person's risk of developing diabetes, hypertension, heart disease and some cancers. While obesity …
Staff
Dr. Guanjie Chen is a senior research fellow with the NHGRI's Center for Research on Genomics and Global Health.
… G, Herbert A, et al. A Genome wide association study of hypertension and blood pressure in African Americans. PLoS … Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African Americans. J …
Staff
Dr. Rongling Li is an epidemiologist and program director in the Division of Genomic Medicine at the National Human Genome Research Institute.
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… de Andrade M, Crawford DC. Genome-wide study of resistant hypertension identified from electronic health records. PLoS … M Barnard, G Somes. Longitudinal relationship of parental hypertension with body mass index, blood pressure, and … health, aging and body composition ctudy. Journal of Human Hypertension , 21:673. 2007. [ PubMed ] CL Wassel-Fyr, AM …
Staff
Dr. Wilson is the co-chief of and senior investigator in NHGRI's Computational and Statistical Genomics Branch.
… association in complex disorders (e.g., traits related to hypertension and cardiovascular disease, depression and … and pleiotropic effects: application to traits related to hypertension. Am J Hum Genet , 48:862-872. 1991. [ PubMed ] …