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The Genomics Landscape
In the October 2019 edition of The Genomics Landscape, NHGRI Director Eric Green focuses on recent efforts to make the human genome reference sequence useful to basic and clinical researchers and how increasing the representation of human genomic variation will remain key components of NHGRI’s Human Genome Reference Program.
… provides comprehensive treatment for inherited blood and immune diseases Genome: Unlocking Life's Code September 2019 …
Staff
Dr. Lanata is a staff clinician in NHGRI's Genomics of Autoimmune Rheumatic Disease Section.
… I, Jain TS, Nititham J, et al. Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus …
News Release
NHGRI hosted a CRISPR "Ask Me Anything" with Jennifer Doudna, Ph.D., reaching 10.5 million people worldwide.
… answered nearly a hundred questions about CRISPR, the immune system, and how CRISPR can be used to treat specific … Innovative Genomics Institute. The recent finding of human immune responses to CRISPR-Cas9 proteins in human cells is an …
News Release
Researchers from NHGRI and the Undiagnosed Diseases Program (UDP) have discovered a new neurological condition characterized by issues with motor coordination and speech.
… could provide insights into how the cell’s recycling system contributes to a healthy brain. … Researchers at the …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… network models, taking advantage of the dynamics of the system as the cells transition from one physiologic state to … PI(s) Institution Study Title (RePORTER Link) Biological System Alexander Hoffmann, Ph.D. and Douglas Black, Ph.D. … Angeles "Ribonomics" Of Gene Regulation To Predict Innate Immune Responses Post-transcriptional response to pathogens, …
Genetic Disorders
Dercum disease is a rare condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of middle age.
… disorder (a condition that occurs when the body's immune system attacks normal, healthy body tissue). However, no …
News Release
NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.
… fins, respectively. Using fluorescently tagged leukocytes (immune cells that flock to the site of injury as part of the … leads the federal government's research on the visual system and eye diseases. NEI supports basic and clinical …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… pathogens. This evolutionary battle is between the human immune system and microorganisms trying to invade our bodies. … response of the body. Pyrin is activated when there is an immune response (for example, in the event of an infection). …
The Genomics Landscape
In the August 2023 edition of The Genomics Landscape, NHGRI Director Eric Green introduces incoming NHGRI DEO Director, Jennifer Troyer.
… practices. … Genomics Research Researchers find weaker immune response to viral infections in children with …
Genetic Disorders
Antiphospholipid Syndrome is a disorder characterized by elevated levels of antibodies that are associated with clots in the arteries and veins.
… to its normal size). Thrombocytopenia An association with immune thrombocytopenia (low platelets) has also been … category of autoimmune disorders (conditions caused by an immune response against the body's own tissues). Individuals …