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National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2021.
… or Bioengineering and Biomedical Imaging Research (R01) 27 Knockout Mouse Phenotyping Project (KOMP2) KOMP2 Program … Consortium RFA-HG-21-036 - Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) RFA-HG-21-037 - Limited Competition: Knockout Mouse Phenotyping Project Data Coordination Center …
News Release
A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… and the fish are far less costly to maintain than are mice. They multiply astonishingly quickly; a female may … Research paper. The CRISPR/Cas9 methodology works in mice, too, but it is more costly and takes far longer. Although mice actually reach sexual maturity earlier than zebrafish, …
Staff
Dr. Lisa Helbling Chadwick is a program director in Division of Extramural Research at the National Human Genome Research Institute.
… HF. Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval . Genetics , … influences on X chromosome choice in Xce heterozygous mice . Mamm Genome, 16(9):691-9. 2005. … Biography … …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2022.
… Emphasis Overview Scientific Areas of Emphasis Search 31 Knockout Mouse Phenotyping Project (KOMP2) KOMP2 Program … Phenotyping Consortium Website Fell et al. – “NIH Renews Knockout Mouse Project for 3rd Time” 32 Human Heredity & …
Event
The 2018 meeting focused on KOMP's collaborations with various human disease gene discovery programs.
… Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… place in the petri dish and in nonhuman organisms such as mice or zebrafish. Researchers rely on genome editing tools … A typical study might be to model human disease in mice by deleting or editing certain genes that are thought to …
About NHGRI
A timeline of notable events in the history of the National Human Genome Research Institute.
… unprecedented access to two private collections of knockout mice , providing valuable models for the study of human … laying the groundwork for a public, genome-wide library of knockout mice. October 26, 2005: The International HapMap …
Research at NHGRI
The Genetic Disease Research Branch studies how genetic changes affect the structure and function of gene products leading to human disease.
… development. Model systems, including genetically altered mice and in vitro cell and organ culture systems, are major …
Staff
Dr. Pamela Schwartzberg is a adjunct investigator in NHGRI's Genetic Disease Research Branch.
… recombination to introduce mutations into the germline of mice — work that helped open a new era in mouse genetics. … genetic primary immunodeficiencies, as well as mutant mice and cell lines, have demonstrated that pathways … Specific projects: Tec Kinases: Through the generation of mice deficient in Rlk and Itk, Dr. Schwartzberg's lab has …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… that affect humans. They edit the genomes of animals, like mice and zebrafish, because animals have many of the same genes as humans. For example, mice and humans share about 85 percent of their genes! By …