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A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… A knockout mouse is a laboratory mouse in which researchers … what that gene normally does. Humans share many genes with mice. Consequently, observing the characteristics of knockout mice gives researchers information that can be used …
Research Funding
The Knockout Mouse Phenotyping Project (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome.
… Jacqueline K The Jackson Laboratory The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2) … Mary E Heaney, Jason D Baylor College of Medicine The BCM Knockout Mouse Production and Phenotyping Project (BCM KOMP2) … the mouse genome. … Humans share most of their genes with mice. Because of this, the laboratory mouse has served as a …
Educational Resources
A knockout typically refers to an organism that has been genetically engineered to lack one or more specific genes.
… Knockout … A knockout typically refers to an organism that has been … engineered to lack one or more specific genes. … Knockout Mouse, Genetic Engineering, Gene, Laboratory Experiment … A knockout, as related to genomics, refers to the use of …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… 2001, and is principally responsible for supervising The Knockout Mouse Project (KOMP). The goal of the KOMP program, … stem (ES) cells. He is now working to implement The Knockout Mouse Phenotyping Project (KOMP2). The goal of this … program is to covert the 8,500 ES cell lines into live mice and then perform broad phenotyping on these strains. …
News Release
Researchers have discovered that FGF21 is elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia.
… growth factor 21 (FGF21), is extremely elevated in mice with liver disease that mimics the same condition in … in their mitochondria, specifically in the liver. The MMA mice also allowed them to study the response to … News Feature: Elevated hormone flags liver problems in mice with methylmalonic acidemia (MMA) … Researchers have …
Talking Glossary
El término knockout, en relación con la genómica, se refiere al uso de ingeniería genética para inactivar o eliminar uno o más genes específicos de un organismo.
… Knockout (modificación por eliminación o inactivación) … El término knockout, en relación con la genómica, se refiere al uso de … eliminar uno o más genes específicos de un organismo. … A knockout, as related to genomics, refers to the use of …
News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… and a rare disorder, Gaucher disease, by cross-breeding mice to carry human mutations causing each of the two … extra copies of a mutated form of alpha-synuclein. These mice were then mated with mice missing a copy of the GBA1 gene. The resulting mice - …
Staff
Lisa Garrett is an associate investigator and director of the NHGRI Transgenic Mouse Core.
… at NCI, Frederick, Maryland. generating transgenic mice for models of cancer. At this time, she started her … will provide more efficient means to generate transgenic mice and provide additional tools for NHGRI investigators to … other useful information for using genetically engineered mice in research. Most recently, Ms. Garrett co-authored the …
Educational Resources
Fact sheets explaining complex concepts in genomics research to a non-scientific audience.
… Acid (DNA), DNA Microarray, DNA Sequencing, Epigenomics, Knockout Mice, Newborn Screening, Cost Of Sequencing A Human Genome, X …
Educational Resources
An animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans.
… humans. … Biomedical Research, Ethics, Animal Experiments, Mice, Rats, Experiment … An animal model is a non-human … process or disease found in humans. Animal models (e.g., mice, rats, zebrafish and others) are sufficiently like …