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Educational Resources
A knockout typically refers to an organism that has been genetically engineered to lack one or more specific genes.
knockout … a knockout typically refers to an organism that has been … engineered to lack one or more specific genes. … knockout mouse, genetic engineering, gene, laboratory … more specific genes. scientists create knockouts (often in mice ) so that they can study the impact of the missing genes …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… a knockout mouse is a laboratory mouse in which researchers … what that gene normally does. humans share many genes with mice . consequently, observing the characteristics of knockout mice gives researchers information that can be used …
Staff
Lisa Garrett is a staff scientist and director of the NHGRI Transgenic Mouse Core.
… at nci, frederick, maryland. generating transgenic mice for models of cancer. at this time, she started her … will provide more efficient means to generate transgenic mice and provide additional tools for nhgri investigators to … other useful information for using genetically engineered mice in research. most recently, ms. garrett co-authored the …
Educational Resources
Fact sheets explaining complex concepts in genomics research to a non-scientific audience.
… acid (dna), dna microarray, dna sequencing, epigenomics, knockout mice , newborn screening, cost of sequencing a human genome, …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… 2001, and is principally responsible for supervising the knockout mouse project (komp). the goal of the komp program, … stem (es) cells. he is now working to implement the knockout mouse phenotyping project (komp2). the goal of this … program is to covert the 8,500 es cell lines into live mice and then perform broad phenotyping on these strains. …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
… some aspect of human physiology or disease. … mouse model, knockout mouse, genetic engineering, laboratory experiment, … of different model organisms are used in this regard, but mice are especially useful because they share mammalian …
Archive
… researchers to gain wider access to knockout mice … archive …
Archive
… 2010 news feature nih receives donation of knockout mice collection … archive …
Archive
… nih launches effort to place more knockout mice in public repositories … archive …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… transgenic mouse core uses crispr to generate laboratory mice with specific gene alterations for the study of human … nhgri researchers take advantage of this resource. the knockout mouse project (komp) is an national institutes of … that nhgri helped develop. it was designed to generate mice containing mutations in every gene of the mouse genome. …