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Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… over and over again. … Researchers now are able to compare large stretches of DNA - 1 million bases or more - from … rare diseases. Other researchers are studying its use in screening newborns for disease and disease risk. Moreover, … of gene regulation in disease. Ongoing and planned large-scale projects use DNA sequencing to examine the development …
Research at NHGRI
The Division of Intramural Research conducts scientific studies in NHGRI's labs on and around the NIH campus in Bethesda, Md.
… greater understanding of human disease and develop better methods for detection, prevention and treatment of heritable … and application of DNA microarray technologies for large-scale analyses of gene expression; creation of innovative …
Staff
Dr. Shawn Burgess is the deputy director of NHGRI's Intramural Research Program.
… Institute of Technology, where he was part of a large effort to develop insertional mutagenesis in zebrafish, … In previous work, Dr. Burgess participated in a large-scale genetic screen for embryonic lethal phenotypes in the … over which genes are inactivated. As a result, targeted screening in a vertebrate is now possible for the first time, …
The Genomics Landscape
In the March 3, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., highlights the new fact sheets produced by the institute's Communications and Public Liaison Branch.
… and educational opportunities to facilitate diverse and large-scale genomic-based analyses in a cloud environment. By … a wider group of researchers and lowers the barrier for large-scale computational research.  In four years, AnVIL …
Research at NHGRI
The Center for Precision Health Research, formerly Medical Genomics and Metabolic Genetics Branch, studies how health and disease are related to genetic, genomic and metabolic variation.
… by applying tools ranging from high-throughput biologic methods, large scale informatics methods, classic bench laboratory …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… anemia and cystic fibrosis are inherited in families, what screening and testing options are available, and, for some … genes in a person or other organism. Due to the success of large-scale biology projects such as the sequencing of the human …
Staff
Dr. Meru Sadhu is the head of the Systems Biology and Genome Engineering Section at the National Human Genome Research Institute. ​
… is immense, the section devises strategies to study large numbers of genetic differences in parallel. These … leverage the strengths of CRISPR technologies, large-scale oligonucleotide synthesis, the power of the yeast model … In addition to applying existing genome engineering methods, the section aims to further expand the reach of …
Educational Resources
NHGRI participates in the South By Southwest (SXSW) conference to help increase genomic literacy.
… technology currently being worked on in genomics including large-scale genetic sequencing, gene editing, artificial …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… Diego, where he oversaw the design and implementation of a large-scale mouse ENU mutagenesis screen. He has been working in …
Fact Sheet
mRNA vaccines inject cells with instructions to generate a protein that is normally found on the surface of SARS-CoV-2, the virus that causes COVID-19.
… safe and effective. Two mRNA vaccines have been tested in large-scale clinical trials that included elderly and medically …