Search Results
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… by developing a massively parallel single-cell mRNA profiling method. Center-developed technologies will be … Chicago Chemical modifications on mammalian messenger RNA (mRNA) have recently been shown to play critical and diverse regulatory roles in mRNA metabolism and translation. For example, the most …
News Release
NHGRI has selected Charles Venditti, M.D., Ph.D., as chief of its Metabolic Medicine Branch within the Institute’s Intramural Research Program. In this role, he will provide leadership and guidance on research into genetic diseases that disrupt metabolism.
News Release
NIH researchers have developed a breath test that measures how well patients with methylmalonic acidemia (MMA) respond to receiving liver or combined liver and kidney transplantation.
… increase in carbon 13 propionate oxidation after gene, mRNA or genome editing therapies,” Venditti said. “This way, …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… kinds of RNA. The major type, called messenger RNA (mRNA), plays a vital role in making proteins. In this process: mRNA is transcribed from genes; then the mRNA transcripts are delivered to ribosomes , the molecular …
For Teachers
Tools and resources for teaching the concepts of transcription and translation, two key steps in gene expression
… of a gene sequence. This copy, called a messenger RNA (mRNA) molecule, leaves the cell nucleus and enters the … process of translating the sequence of a messenger RNA (mRNA) molecule to a sequence of amino acids during protein … the cell cytoplasm, the ribosome reads the sequence of the mRNA in groups of three bases to assemble the protein. Here …
Partner with NHGRI
NHGRI's technologies, inventions and discoveries are available for licensing.
… are available for licensing, including candidate gene therapy-based therapeutics, mouse models of genetic disorders … Ph.D. (NHGRI) Office of Technology Transfer Abstract Gene Therapy for Niemann-Pick Disease Type C (NPC) DHHS Reference …
Policy Issues
In 2008, the Genetic Information Nondiscrimination Act was passed into law, prohibiting discrimination by employers and health insurers.
Fact Sheets
Deoxyribonucleic acid (DNA) is a molecule that contains the biological instructions that make each species unique.
… molecule called messenger ribonucleic acid, or mRNA. Next, the information contained in the mRNA molecule is translated into the "language" of amino … a template. This template strand is then transcribed into mRNA, which is a molecule that conveys vital instructions to …
The Genomics Landscape
In the June 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D. details the upcoming appointment of acting NHGRI Deputy Director, Vence Bonham Jr., J.D. and what it means for the institute.
… for disease gene mapping. … Genomics Research Gene therapy restores immune function in children with rare … COVID-19 screening guidelines Studies Confirm COVID-19 mRNA Vaccines Safe, Effective for Pregnant Women COVID-19 mRNA Vaccine Q&A with Dr. Kizzmekia S. Corbett NIH clinical …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… either by genes in the Ensembl database, or by human mRNA best BLAT (BLAST-like alignment tool) alignments in the … and which did not correspond to Ensembl genes, GenBank mRNA BLASTZ alignments, Fgenesh++ gene predictions, TwinScan …