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News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… most common, age-related dementia. "These new cellular models of Gaucher disease are helping to better explain the …
Research Funding
The primary mission of the Alliance of Genome Resources (the Alliance) is to develop and maintain sustainable genome information resources that facilitate the use of diverse model organisms in understanding the genetic and genomic basis of human biology, health and disease. This understanding is fundamental for advancing genome biology research and for translating human genome data into clinical utility.
Staff
Dr. Shurjo Sen is a program director in NHGRI's Division of Genome Sciences who manages a portfolio of grants focused upon genomic data sciences, and is particularly interested in transitioning genomics from a centralized data repository model to cloud-based collaborative science.
Staff
Valentina Di Francesco is NHGRI's Chief Data Science Strategist and Director of the Office of Genomic Data Science within the NHGRI Office of the Director.
Staff
Dr. Raman Sood is an associate investigator in the Translational and Functional Genomics Branch and director of the Zebrafish Core at the National Human Genome Research Institute.
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… cloning to functional genomic analyses using animal models. She has participated in several collaborative … functioning splicing machinery in leukemogenesis. Animal models play a critical role in understanding the genetic … exome sequencing or transcriptome profiling), zebrafish models can be established to validate its role in the disease …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… therapies can be developed and tested. Many of these mouse models are named after the gene that has been inactivated. … cancer and blood cancers at an early age.Other mouse models are named, often with creative flair, according to …
Staff
Dr. Shawn Burgess is the deputy director of NHGRI's Intramural Research Program.
… will also be targeted, in order to create new animal models relevant to one of the most common health problems in … cell signaling molecules to generating animal models for rare genetic diseases. For example, his lab is … genetic mutation, Undiagnosed Diseases Network, animal models of disease … Dr. Shawn Burgess is the deputy director …
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… "The mouse has long been a mainstay of biological research models," said NHGRI Director Eric Green, M.D., Ph.D. "These … Bing Ren, Ph.D., John Stamatoyannopoulos, M.D., mouse models for genetic research … Researchers have found powerful …
News Release
NIH recently awarded approximately $6.8 million in grants to several research teams to study the biology of rare and undiagnosed diseases.
… Center, scientists use zebrafish and fruit flies as models to examine how differences in the DNA code - called …