Search Results
Talking Glossary
cDNA (short for copy DNA; also called complementary DNA) is synthetic DNA that has been transcribed from a specific mRNA through a reaction using the enzyme reverse transcriptase
… reverse transcriptase. While DNA is composed of both coding and non-coding sequences, cDNA contains only coding sequences. …
Event
A 10-part seminar series in 2021 that focuses on the “Bold Predictions for Human Genomics by 2030” that are described in NHGRI’s “Strategic Vision for Improving Human Health at the Forefront of Genomics.”
… function(s) of every human gene will be known; for non-coding elements in the human genome, such knowledge will be … #7: The clinical relevance of all encountered genomic variants will be readily predictable, rendering the …
Staff
Dr. Mike Pazin is a program director in the Division of Genome Sciences at the National Human Genome Research Institute.
… Elements from the human and mouse genomes, as well as the Non-Coding Variants (NoVa) program . Mike is part of the Common Fund …
News Release
CMG investigators have made significant inroads in discovering genes underlying Mendelian conditions and have uncovered 470 new, previously unknown conditions.
… genome sequencing. The exome includes all the protein-coding genes in the genome. Proteins are the work horse of … Dr. Lifton wonders about the potential effects of the non-protein-coding regions of the genome on Mendelian … an open question as to how much influence mutations in non-coding elements that regulate gene activity will have on …
Research Funding
The Genomic Variation Program supports large-scale studies of human genetic variation.
… a higher or lower risk for getting particular diseases. Variants in single genes cause some traits and diseases, such … … Information Related to the Genomic Variation Program Non-Coding Variants Program (NoVa) 1000 Genomes: A Deep Catalog …
News Release
NHGRI researchers will present four platform talks and 55 posters to highlight the institute's diverse portfolio at the 65th annual meeting of ASHG.
… Genetics) 716W. Guanjie Chen: Common and Rare Exonic Variants Associated with Type 2 Diabetes in Han Chinese. … for Genetic Disorders) 527T. Surjo K. Sen: STEM9, a novel non-coding RNA on chromosome 9p21, is downregulated in coronary …
Educational Resources
An exon is the portion of a gene that codes for amino acids.
… that ends up within an mRNA molecule. Some exons are coding, in that they contain information for making a protein, whereas others are non-coding. Genes in the genome consist of exons and introns. … …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… that codes for a microRNA molecule. MicroRNAs are small, non-coding RNA molecules involved in the regulation of gene …
Funding Opportunities
Funding Opportunities for Investigator-Initiated Research in Computational Genomics and Data Science
The Computational Genomics and Data Science Program Announcements (PARs) invite applications for investigator-initiated research efforts fostering innovation in computational genomics, data science, statistics, bioinformatics, and data visualization and exploration.
… with an application to understanding the impact of non-coding variation on neuropsychiatric diseases HG010773 KERN, … of Genomes to Classify Somatic and Pathogenic Structural Variants HG011774 JERNIGAN, ROBERT L IOWA STATE UNIVERSITY …
Educational Resources
Gene expression is the process by which the information encoded in a gene is used to direct the assembly of a protein molecule.
… transcription of RNA molecules that code for proteins or non-coding RNA molecules that serve other functions. Gene …