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Educational Resources
Non-coding DNA corresponds to the portions of an organism’s genome that do not code for amino acids, the building blocks of proteins.
… Non-Coding DNA … Non-coding DNA corresponds to the portions of an organism’s …
Research Funding
The N​on-Coding Variants Program explores which variants in a region associated with a disease or trait cause the higher risk for the disease or trait
… genome differ among those people. Some of these genetic variants are common, such as the variants for blood types (A, … ones that contribute to disease risk, are not in protein-coding regions. These functional variants generally affect … that determine when and where proteins are made. The Non-Coding Variants Program (NoVa) supports the development …
Educational Resources
Antisense is the non-coding DNA strand of a gene.
… Antisense … Antisense is the non-coding DNA strand of a gene. … Non-coding DNA, Messenger RNA, Protein Synthesis … Antisense …
News Release
Researchers recommend genomic approaches to discovering inherited variants in one or a handful of genes that affect an individual's rare disease risk.
… technologies can generate detailed catalogs of genomic variants, researchers face an ongoing challenge of distinguishing variants that cause disease from those that do not. … genome contains between three and four million genomic variants, which are specific changes in DNA sequence. … …
News Release
NIH and Inova Health are launching The Genomic Ascertainment Cohort, a pilot project that will examine gene and gene variant influence on phenotypes.
… the health consequences of their genes and gene variants. … Reversing a Long-Standing Paradigm To address … to recall genotyped people and examine the genes and gene variants' influence on their phenotypes, an individual's … the 1-2 percent of the genome that contains protein-coding genes. Once the database is established, NIH and Inova …
Educational Resources
Microsatellite sequences are repetitive DNA sequences usually several base pairs in length.
… usually several base pairs in length. … DNA Sequence, Non-coding DNA, Genetic Markers, Inherence, ACGT … … genomic location. These DNA sequences are typically non-coding. The number of repeated segments within a …
Educational Resources
A tandem repeat is a sequence of two or more DNA base pairs that is repeated in such a way that the repeats lie adjacent to each other on the chromosome.
… Deoxyribonucleic Acid (DNA), DNA Fingerprinting, Non-Coding DNA … A tandem repeat is a sequence of two or more DNA … on a chromosome. Tandem repeats are generally present in non-coding DNA. In some cases, tandem repeats can serve as …
Educational Resources
A telomere is the end of a chromosome.
… … Cell, Chromosome, Deoxyribonucleic Acid (DNA), Non-Coding DNA … A telomere is a region of repetitive DNA …
Talking Glossary
When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS).
… significance (abbreviated VUS). In many cases, these variants are so rare in the population that little …
News Release
As researchers uncover millions of DNA differences in genes, doctors struggle to know which of these inherited differences, called variants, really matter.
… struggled to know which of these inherited differences - variants - really matter. … For the vast majority of the more than 80 million variants discovered to date, researchers know little about … and researchers hope to use information about genomic variants to evaluate individual disease risk, make better …