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Educational Resources
An intron is a portion of a gene that does not code for amino acids.
… that does not code for amino acids. … Intron, Exon, Amino Acid, DNA Sequence, Gene … An intron is a region that resides …
Research Funding
CSER is rapidly advancing the knowledge necessary to develop best practices for implementating genomic sequence data into clinical care.
… Reports of genomic sequencing being applied to the medical care of individual … most likely to be usefully addressed by a genomic sequencing approach still accumulating. Incorporation of … co-funding from NCI, subsequently crafted the Clinical Sequencing Exploratory Research (CSER) initiative to: 1) …
Staff
Dr. Gerard Bouffard directs the Bioinformatics Group at the NIH Intramural Sequencing Center (NISC).
… where he combined his interests in early genome sequencing of the Escherichia coli genome with the nascent … sequencing of cDNA clones using the transposon Tn5. Nucleic Acids Res , 30(11):2469-77. 2002. [ PubMed ] Wistow … and genome portal for hematology and erythroid biology. Nucleic Acids Res , 1;32(Database issue):D572-4. 2004. [ …
News Release
NIH researchers have developed and released an innovative software tool, called Verso, to assemble truly complete (i.e., gapless) genome sequences from a variety of species. The software makes the process of assembling complete genome sequences more affordable and accessible.
… complete genome sequence.” The T2T consortium used new DNA sequencing technologies and analytical methods to generate … like putting together a jigsaw puzzle, and different DNA sequencing technologies generate different types of genomic … researchers tested Verkko with human and non-human genome sequencing data. The software quickly and precisely assembled …
Educational Resources
A contig is a series of overlapping DNA sequences used to make a map that reconstructs the original DNA sequence of a chromosome or a region of a chromosome.
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… biology of living things have changed over time. As DNA sequencing technology becomes more powerful and less … both plants and animals, consist of DNA (deoxyribonucleic acid), the chemical chain that includes the genes that code … list continues to grow almost daily. In addition to the sequencing of the human genome, which was completed in 2003, …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… Mullikin pioneered DNA sequencing technologies during the Human Genome Project and … the whole progress, from the very early days of Sanger sequencing all the way to a complete telomere-to-telomere … NISC has evolved in tandem with rapidly advancing DNA sequencing technologies. When I was appointed acting director …
Educational Resources
Polymorphism involves one of two or more variants of a particular DNA sequence.
… a particular DNA sequence. … Base Pair, Deoxyribonucleic Acid (DNA), Genotype, Mutation, Phenotype … Polymorphism, as …
News Release
New grants totaling approximately $29.5 million will enable scientists to generate and maintain the most comprehensive reference sequence of the human genome.
… The funds are necessary for making advances in DNA sequencing technology and computational methods possible. As … will represent 350 genomes from the human population. The sequencing of the human genome was a landmark achievement in … The second component – the Human Reference Genome Sequencing Center - aims to sequence up to 350 additional …
Educational Resources
A stop codon is a trinucleotide sequence within a messenger RNA (mRNA) molecule that signals a halt to protein synthesis.
… synthesis. … Amino Acids, Cell, Codon, Deoxyribonucleic Acid (DNA), Gene Environment Interaction, Genetic Code, …