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… Walter Gilbert GenBank First human disease gene — for The polymerase DNA-sequencing instrument human genetic Human … is issued methods established with DNA markers genome chain reaction (PCR) is invented developed map developed …
News Release
Researchers recommend more rigorous clinical study of dietary management practices for patients with IEMs, which may result in reformulating some medical foods.
… the recommended amounts of leucine. Leucine is a branched chain amino acid essential to liver, muscle and adipose … in excess, it causes a depletion of the other branched chain amino acids, valine and isoleucine. This might have … cannot adequately synthesize the amino acid methionine, a reaction that depends on vitamin B12. As a result, management …
Staff
Dr. Peter McGuire is an investigator in NHGRI's Center for Precision Health Research.
… have highlighted their role as a major node in this immune reaction.] The group also studies intermediary metabolism and … mtDNA replication and stability, or (E) the respiratory chain. Genes listed were compiled from MitoMap.] This … V. McGuire, P.J., Lee, P.R. Child neurology: Medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency. …
News Release
Micro-sized technologies are among the approaches researchers will use to develop high quality, low cost DNA sequencing technology.
… to convert the product of a single molecule DNA sequencing reaction into many copies of a reporter molecule that are … will study a system to sequence DNA using an enzyme (polymerase) on a carbon nanotube, in an array format. Carbon …
For Teachers
Lesson plan based on an award-winning DNA from the Beginning website, an animated primer on the basics of DNA, genes and heredity.
… copying the whole. How did the discovery of the enzyme DNA polymerase play in the understanding for the process of DNA … proved that base pairing was important for a self-splicing reaction in RNA? #27. Mutations are changes in genetic …
Staff
Dr. Daniel Gilchrist is a program director of Computational Genomics and Data Science in NHGRI's Division of Genome Science.
… Burkholder A, Fargo DC, Adelman K. Stable pausing by RNA polymerase II provides an opportunity to target and integrate … G, Fargo DC, Xie B, Gao Y, Li L, Adelman K. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization … R, Parker JS, Grissom SF, Zeitlinger J, Adelman K. RNA polymerase is poised for activation across the genome. Nat …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… of the ENCODE pilot project. Antibodies that recognize RNA polymerase II and TAFII250, a component of a general … that initiates the preinitiation complex assembly for RNA polymerase II, should be bound to the promoters of all genes actively transcribed by RNA polymerase II. The RNA polymerase II antibody is available …
Educational Resources
An enzyme is a biological catalyst and is almost always a protein.
… a protein. It speeds up the rate of a specific chemical reaction in the cell. The enzyme is not destroyed during the reaction and is used over and over. A cell contains thousands … enzyme molecules, each specific to a particular chemical reaction. … An enzyme is a biological catalyst and is almost …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… or closes in response to light, and affect the skin's reaction to changing temperature. Biological pathways do not … by specialized proteins that trigger a specific reaction in the cell. For example, a chemical signal from …
Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… … One new sequencing technology involves watching DNA polymerase molecules as they copy DNA - the same molecules …