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Educational Resources
A stem cell is a cell with the potential to form many of the different cell types found in the body.
stem cell … a stem cell is a cell with the potential to form many of the … of the different cell types found in the body. when stem cells divide, they can form more stem cells or other cells that perform specialized functions. …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… cell to its earliest stage of development (a pluripotent stem cell ) and change it into different types of cells in the body. … called induced pluripotent stem cells (ipscs), this technique opens the doors to medical …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… its make-up is different among cell types, even among cells that are similar. investigators from two national human … what to do - among three types of cells : mouse embryonic stem (es) cells , embryonic fibroblasts and hematopoietic … subtypes based on chromatin make-up. they found that each stem cell subtype had a different ability to develop into …
Media Availability
TCGA researchers have found that chromophobe renal cell carcinoma stems partly from gene alterations in the mitochondria, the cell's energy supplier.
Staff
Cynthia Tifft, M.D., Ph.D. is the deputy clinical director for the National Human Genome Research Institute.
… by inhibiting activation of macrophage-derived microglial cells leading to neuronal apoptosis. this was the first … the proia/tifft team have generated induced pluripotent stem (ips) cells from a patient with infantile sandhoff … derived from sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation. j. lipid …
Staff
Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… served on the scientific advisory boards of the center for stem cell and regenerative medicine, the national disease … process of generating all of the different types of blood cells (erythrocytes, lymphocytes, platelets, etc.) … from a small population of pluripotent hematopoietic stem cells. as pluripotent hematopoietic stem and progenitor …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… 8,500 knockouts of mouse genes, in the form of embryonic stem (es) cells . he is now working to implement the knockout mouse … mouse phenotyping project (komp2), mouse genes, embryonic stem cells … colin fletcher, knockout mouse project (komp), …
Staff
Dr. Manfred Boehm is a an adjunct investigator for the Office of the Clinical Director at NHGRI.
… boards of trends in cardiovascular medicine , isrn stem cells , atherosclerosis , and journal of molecular medicine . … diseases, precision medicine, human induced pluripotent stem cells (hipscs), arterial calcification … manfred boehm, …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… disease.   … researchers begin by harvesting embryonic stem (es) cells from early-stage mouse embryos four days after … mouse, animal model, laboratory experiment, dna, embryonic stem cells , homologous recombination … a knockout mouse is a …
Staff
Dr. Paul Liu is NHGRI's deputy scientific director and a senior investigator in NHGRI's Translational and Functional Genomics Branch. ​
… during leukemia development by microarray analysis with cells from cbfb-myh11 knock-in mice, and identified … made novel findings regarding its role in hematopoietic stem cell production (bresciani, blood in press). overall the … hematopoiesis, especially the formation of hematopoietic stem cells , from fresh angles and in great detail. germline …