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Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
News Release
NIH will fund researchers to develop computational approaches to figure out which differences in DNA make people more susceptible to disease.
… inherited genetic variants that cause changes in gene regulation associated with cancer. Georgia Institute of …
News Release
NHGRI-funded researchers to be honored with Presidential Early Career Awards for Scientists and Engineers
… his innovative approaches to the study of transcriptional regulation. By using a suite of new technologies, Dr. Sanjana …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… Dr. Pavan's group first discovered the neural crest cell transcription factor SOX10 , which is associated with … Pavan's section discovered that mutations of the HMG-box transcription factor SOX10  result in neural crest stem cell … patterns of SOX10 binding and putative SOX10 target regulation, and also revealed a melanocyte-specific, …
Educational Resources
Gene expression is the process by which the information encoded in a gene is used to direct the assembly of a protein molecule.
… gene is turned into a function. This mostly occurs via the transcription of RNA molecules that code for proteins or …
Staff
Dr. Sharon Milgram is an adjunct investigator in the Genetics and Molecular Biology Branch at the National Human Genome Research Institute.
… ] Smith PM, Cowan A, Milgram SL, White BA. Tissue-specific regulation by estrogen of ezrin and … and regulates its co-activation of p73-mediated Bax transcription. J Biol Chem , 279:26300-26306. 2004. [ PubMed … E, Kultgen P, Barnes AP, Milgram S, and Stutts MJ. Local regulation of cystic fibrosis transmembrane regulator and …
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… speed, and comprehensiveness of understanding genome regulation. We will develop new technologies to interrogate … microscopy- based phenotyping technology, and on global transcription by developing a massively parallel single-cell … have been shown to regulate chromatin state and transcription, and intron modifications may affect pre-mRNA …
Staff
Jennifer Strasburger was the lead Genomic Program Administrator (GPA) for NHGRI as well as the co-chair for the NHGRI Data Access Committee (DAC).
… a portfolio of grants focused on post-transcriptional gene regulation. Her NCI portfolio also included grants focused on …
Staff
Dr. Heidi Sofia served as a program director in the Division of Genomic Medicine at the National Human Genome Research Institute from 2010-2023.
… W.G. Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum …
Research Funding
MorPhiC aims to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene by using in-vitro multicellular systems.