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A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… and the fish are far less costly to maintain than are mice. They multiply astonishingly quickly; a female may … Research paper. The CRISPR/Cas9 methodology works in mice, too, but it is more costly and takes far longer. Although mice actually reach sexual maturity earlier than zebrafish, …
Staff
Dr. Lisa Helbling Chadwick is a program director in Division of Extramural Research at the National Human Genome Research Institute. ​
… HF. Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval . Genetics , … influences on X chromosome choice in Xce heterozygous mice . Mamm Genome, 16(9):691-9. 2005. … Biography … …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… place in the petri dish and in nonhuman organisms such as mice or zebrafish. Researchers rely on genome editing tools … A typical study might be to model human disease in mice by deleting or editing certain genes that are thought to …
Staff
Dr. Charles Venditti is a chief and senior investigator of NHGRI's Metabolic Medicine Branch.
… acid metabolism in model organisms, including roundworms, mice and zebrafish. Using a translational research approach, … all the studies are striking: while the untreated Mut-/- mice uniformly perish in early life, the Mut-/- mice that receive AAV gene therapy with any of the section's …
Research at NHGRI
The Genetic Disease Research Branch studies how genetic changes affect the structure and function of gene products leading to human disease.
… development. Model systems, including genetically altered mice and in vitro cell and organ culture systems, are major …
Staff
Dr. Pamela Schwartzberg is a adjunct investigator in NHGRI's Genetic Disease Research Branch.
… recombination to introduce mutations into the germline of mice — work that helped open a new era in mouse genetics. … genetic primary immunodeficiencies, as well as mutant mice and cell lines, have demonstrated that pathways … Specific projects: Tec Kinases: Through the generation of mice deficient in Rlk and Itk, Dr. Schwartzberg's lab has …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… that affect humans. They edit the genomes of animals, like mice and zebrafish, because animals have many of the same genes  as humans. For example, mice and humans share about 85 percent of their genes! By …
Staff
Dr. Sharon Milgram is an adjunct investigator in the Genetics and Molecular Biology Branch at the National Human Genome Research Institute.
… biochemical assays to physiological assays in knock-out mice. … Altschuler Y, Hodson C, Milgram SL. The apical … chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol , …
Staff
Darryl Leja is a senior graphic designer, illustrator and visual information specialist within NHGRI's Office of Communications.
… entitled "Training in Basic Biomethodology for Laboratory Mice," DNA Day, the Genome Unlocking Life’s Code Exhibit on …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… program is to covert the 8,500 ES cell lines into live mice and then perform broad phenotyping on these strains. …