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Staff
Dr. Shawn Burgess is the deputy director of NHGRI's Intramural Research Program.
… supporting cells in the lateral line using the SCM1:EGFP transgenic zebrafish line. BMC Dev Biol, 12:6. 2012. [ PubMed …
News Release
The largest genomic study on type 2 diabetes in Africans to date has recently been published in Nature Communications and reports the most recent findings of the ongoing Africa America Diabetes Mellitus (AADM) study that has been led by Dr. Charles Rotimi for over two decades.
… functional studies of this locus in zebrafish and mice, researchers discovered that ZRANB3 plays a role in the …
Fact Sheets
Cloning describes a number of different processes that can be used to produce genetically identical copies of a biological entity.
… 1979, researchers produced the first genetically identical mice by splitting mouse embryos in the test tube and then … the resulting embryos into the wombs of adult female mice. Shortly after that, researchers produced the first … cell division. In other mammals, such as cats, rabbits and mice, the two spindle proteins are spread throughout the egg. …
News Release
NHGRI researchers will present four platform talks and 55 posters to highlight the institute's diverse portfolio at the 65th annual meeting of ASHG.
… alleles in the vitamin B12 receptor, CD320, in humans and mice. (Molecular Basis of Mendelian Disorders) 2819W. … carriers. (Metabolic Disorders) *2313T. Peter J. McGuire: Mice lacking Cox10 in T-lymphocytes recapitulate the immune … c. 49G>A, p. Glu17Lys causes embryonic lethality in mice. (Molecular Basis of Mendelian Disorders) 11:45-12:45 …
About NHGRI
A timeline of notable events in the history of the National Human Genome Research Institute.
… Institute and other scientists successfully create transgenic animals  using sperm genetically modified and … access to two private collections of knockout mice , providing valuable models for the study of human … groundwork for a public, genome-wide library of knockout mice. October 26, 2005: The International HapMap Consortium …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… in basic research. Editing the genomes of yeast, bacteria, mice, zebrafish, and other organisms that scientists commonly … and price. … [1] Capecchi, M. R. (2005). Gene targeting in mice: functional analysis of the mammalian genome for the …
News Release
Researchers have identified genomic mutations for Carey-Fineman-Ziter syndrome, a congenital myopathy with facial weakness, a cleft palate and scoliosis.
… to all three. A knockout mouse model (genomically altered mice that are bred to lack a specific gene) displayed a … muscle development, leading to early death of the newborn mice, making this gene a promising candidate for further …
Staff
Dr. Francis Collins is a senior investigator in Center for Precision Health Research.
… the disease seen in HGPS patients. Specifically, these mice exhibit progressive loss of vascular smooth muscle cells … prevented the onset of cardiovascular disease in young mice but also reduced the progression of the cardiovascular defects upon treatment of older mice. This research complemented other data in support of a …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… also the genomes of important research organisms, such as mice, C. elegans and zebrafish. Throughout the Human Genome …
The Genomics Landscape
In the January 2019 edition of The Genomics Landscape, NHGRI Director Dr. Eric Green honors NIAMS Director, Stephen Katz, M.D., Ph.D.
… Genomics Research Elevated Hormone Flags Liver Problems in Mice with Methylmalonic Acidemia Zooming in on Meiosis …