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News Release
A genetic mutation that triggers bladder cancer in dogs is identical to a mutation that is implicated in multiple human cancers.
… BRAF -targeted therapy strategies," they added. Canine tumors carrying the mutation also offer a new environment for … high frequency of the mutation, examination of the dog tumors might enable us to determine why this particular …
Staff
Dr. Paul Meltzer is an adjunct investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… methylation reprogramming in testicular germ cell tumors . Genome Res, 26(11):1490-1504. 2016. Li J, Woods SL, …
The Genomics Landscape
In the June 2018 issue of The Genomics Landscape, NHGRI Director Eric Green highlights the success of The Cancer Genome Atlas.
… with an unprecedented understanding of how, where, and why tumors arise in humans, enabling better informed clinical …
Staff
Dr. Eggerton Campbell is a senior licensing and patenting manager in the Technology Transfer Office at the National Human Genome Research Institute. ​
… nucleic acid amplification (PCR), detection of tumors/cancer via mutations, recombinant polypeptides, human …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… biological pathways and the genetic profiles of particular tumors, drug developers might be able to focus their … likely to repair the pathways affected in their particular tumors. … How do biological pathways work? … What are some …
Staff
Dr. Heidi Parker is an Associate Investigator in the Comparative Genetics Section of the Cancer Genetics and Comparative Genomics Branch, NHGRI.
… and complex trait mapping and genomic analysis of canine tumors. The primary goal of Dr. Parker’s research is to use … and shared regions of dysregulation with human bladder tumors . BMC Cancer 24;20(1):251, 2020. Parker HG*, Whitaker …
Event
On February 16, 2023, the National Human Genome Research Institute (NHGRI) held a follow-up working group consultation after the 14th Genomic Medicine meeting, Genomic Medicine XIV: Genomic Learning Healthcare Systems.
News Release
NIH researchers have discovered a rare and sometimes lethal inflammatory disease - otulipenia - that primarily affects young children.
Educational Resources
Genetic testing is the use of a laboratory test to look for genetic variations associated with a disease.
… Genetic testing is also used to study the genomes of tumors in cancer cases. … Genetic testing is the use of a …
Staff
Dr. Settara Chandrasekharappa is an associate investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… neoplasia type 1 (MEN1), a condition characterized by tumors primarily of the parathyroid, pituitary and endocrine …