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Research at NHGRI
The Division of Intramural Research conducts scientific studies in NHGRI's labs on and around the NIH campus in Bethesda, Md.
… disease genes, including those implicated in cancer, diabetes, premature aging, hereditary deafness, various …
Genetic Disorders
WAGR syndrome is a genetic condition caused by a deletion of genes located on chromosome 11, often causing eye problems and increased risk of cancer in babies.
… one half of individuals who have WAGR syndrome develop a type of kidney cancer called Wilms' tumor. In the early … with WAGR syndrome may have a higher risk for a type of cancer called gonadoblastoma, a cancer of the cells …
Fact Sheet
Currently, there are different gene therapy approaches available through clinical trials.
… stem cells) are cells that can develop into any type of blood cell in your body, such as white blood cells, …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… study of complex diseases such as heart disease, asthma, diabetes, and cancer because these diseases are typically … diet and exercise plans to prevent or delay the onset of type 2 diabetes in people who carry genetic predispositions to …
Research Funding
The PAGE Consortium investigates ancestrally diverse populations to gain a better understanding of how genetic factors influence susceptibility to disease.
… variants, variant annotation, and specific traits (lipids, diabetes/obesity, CHD/ECG, cancer, hypertension/kidney, … on cancer, cardiovascular disease, lipids, obesity, type 2 diabetes, menopause/menarche, the Metabochip and …
File
… and Risk Evaluation Risk checklist and calculator For Type 2 diabetes Heart Disease First degree relatives First degree …
Research Funding
Polygenic RIsk MEthods in Diverse populations (PRIMED) Consortium will work together to develop and implement approaches to integrating extant genotype and phenotype data for the purpose of conducting and disseminating Consortium-wide PRS analyses.
… Ng, Alisa Manning Development of Polygenic Risk Scores for Diabetes and Complications Across the Life-Span in …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
… up during the COVID-19 pandemic to sequence SARS-CoV-2 genomes and immune-response transcriptomes collected as … use in interpretable genotype-phenotype learning; and Type 2 diabetes as a model to show how a person’s health is restored …
The Genomics Landscape
In the June 2019 edition of The Genomics Landscape, NHGRI Director Eric Green details the legacy of the Human Microbiome Project as it reaches completion.
… touring North America. Next : September 12, 2019 – January 2, 2020 Turtle Bay Exploration Park Redding, CA After : … birth, onset of inflammatory bowel disease, and onset of type II diabetes. iHMP researchers found that certain microbes (and …