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Staff Scientist

Center for Research on Genomics and Global Health

Education

B.A. Guilford College, 1995

B.S. LaSalle University, 2003

Ph.D. Cornell University, 2010

Biography

Amy R. Bentley is a Staff Scientist with the Center for Research on Genomics and Global Health (CRGGH). Her primary interest is in the complex interplay between genetic and environmental factors, particularly nutrition, in the etiology of chronic diseases. She was drawn to the CRGGH by the opportunity to investigate this complexity in the context of diverse populations and the accompanying spectrum of variation in both genetic and environmental backgrounds. Her work at the CRGGH centers on the genomics of serum lipid concentrations in populations of African ancestry and on the ways genomics research can exacerbate or ameliorate health disparities.

Dr. Bentley graduated from Guilford College in 1995 with a B.A. in English and Spanish and a minor in East Asian Studies after completing semesters abroad in Beijing, China and Guadalajara, Mexico. After working at the University of Pennsylvania’s English Language Programs for several years, Dr. Bentley returned to school, completing a B.S. in Nutrition from LaSalle University in 2003. With the support of an NIH training grant, Dr. Bentley did graduate work at Cornell University’s Division of Nutritional Sciences with a focus on nutritional epidemiology and chronic disease. After initial work on genetic risk factors associated with folate metabolism and risk of breast cancer in the Nurses’ Health Study, Dr. Bentley’s research centered on antioxidant defenses and pulmonary function in the Health, Aging, and Body Composition Cohort. Specifically, her work focused on the changes in the pulmonary response to the oxidative stress from cigarette smoking that were associated with genetic variation in antioxidant enzymes or with dietary antioxidant intake.

Curriculum Vitae

Publications

Liu C-T, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MCY, Hivert M-F, Lu Y, An P,Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, Li M, Lipovich L, Rybin DV, Taylor KD, Agyemang C, Palmer ND, Cade BE, Chen W-M, Dauriz M, Delaney JAC, Edwards TL, Evans DS, Evans MK, Lange LA, Leong AS, Liu J, Liu Y, Nayak U, Patel SR, Porneala BC, Rasmussen-Torvik LJ, Snijder MB, Stallings S, Tanaka T, Yanek LR, Zhao W, Becker DM, Bielak LF, Biggs ML, Bottinger EP, Bowden DW, Chen G, Correa A, Couper DJ, Crawford DC, Cushman M, Eicher JD, Fornage M, Franceschini N, Fu Y-P, Goodarzi MO, Gottesman O, Hara K, Harris TB, Jensen RA, Johnson AD, Jhun MA, Karter AJ, Keller MF, Kho AN, Kizer JR, Krauss R, Langefeld CD, Li X, Liang J, Liu S, Lowe WL, Mosley TH, North KE, Pacheco JA, Peyser PA, Patrick AL, Rice KM, Selvin E, Sims M, Smith JA, Tajuddin SM, Vaidya D, Wren MP, Yao J, Zhu X, Ziegler JT, Zmuda JM, Zonderman AB, Zwinderman AH, AAAG Consortium, CARe Consortium, COGENT Consortium, eMERGE Consortium, MEDIA Consortium, Adeyemo A, Boerwinkle E, Ferrucci L, Hayes MG, Kardia SLR, Miljkovic I, Pankow JS, Rotimi CN, Sale MM, Wagenknecht LE, Arnett DK, Chen I, Nalls MA, MAGIC Consortium, Province MA, Kao WHL, Siscovick DS, Psaty BM, Wilson JG, Loos RJF, Dupuis J, Rich SS, Florez JC, Rotter JI, Morris AP, Meigs JB. Trans-ethnic Meta-Analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. AJHG (in press). 2016.

Adebamowo SN, Adeyemo AA, Tekola-Ayele F, Doumatey AP, Bentley AR, Chen GJ, Zhou J, Shriner D, Fasanmade, OA, Okafor G, Eghan B Jr, Agyenim-Boateng K, Adeleye J, Balogun W, Amoah AG, Owusu S, Acheampong J, Johnson T, Oli J, Adebamowo CA, Rotimi Cn. Impact of Type 2 Diabetes on Impaired Kidney Function in Sub-Saharan African Populations. Front Endocrinol, 2016; May 30 (epub ahead of print)

Shriner D, Kumkhaek C, Doumatey AP, Chen GJ, Bentley AR, Charles BA, Zhou J, Adeyemo A, Rodgers GP, Rotimi CN. Evolutionary context for the association of γ-globin, serum uric acid, and hypertension in African Americans. BMC Medical Genetics, 2015; 16(103).

Shriner D, Bentley AR, Doumatey AP, Chen G, Zhou J, Adeyemo A, Rotimi CN. Phenotypic variance explained by local ancestry in admixed African Americans. Front Genet, 2015 October 29 (epub ahead of print).

Tekola-Ayele F, Doumatey AP, Shriner D, Bentley AR, Chen G, Zhou J, Fasanmade O, Johnson T, Oli J, Okafor G, Eghan BA Jr., Agyenim-Boateng K, Adebamowo C, Amoah A, Acheampong J, Adeyemo A, Rotimi CN. Genome-wide association study identifies African- ancestry specific-variants for metabolic syndrome. Mol Genet Metab, 2015 Oct 23 (epub ahead of print).

Chen G, Yuan A, Shriner D, Tekola-Ayele F, Zhou J, Bentley AR, Zhou Y, Wang C, Newport MJ, Adeyemo A, Rotimi CN. An Improved Fst Estimator. PLOS One, 2015; 10 (8): e0135368.

Bentley AR, Divers J, Shriner D, Doumatey AP, Gutierrez OM, Adeyemo AA, Freedman BI, Rotimi CN. APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans. BMC Genomics, 2015; 16:421.

Bentley AR, Chen G, Shriner D, Doumatey AP, Zhou J, Huang H, Mullikin JC, Blakesley RW, Hansen NF, Bouffard GG, Cherukuri PF, Maskeri B, Young AC, Adeyemo AA, Rotimi CN. Gene-based Sequencing Identifies Lipid-Influencing Variants with Ethnicity-Specific Effects in African Americans. PLOS Genetics, 2014; 10(3):e1004190

Tang W, Bentley AR, Kritchevsky SB, Harris TB, Newman AB, Bauer DC, Meibohm B, and Cassano PA for the Health ABC Study. Genetic Variation in Antioxidant Enzymes, Cigarette Smoking and Longitudinal Change in Lung Function. Free Radic Biol Med. 2013 Oct; 63:304-12.

Hancock DB*, Soler Artigas M*, Gharib SA*, Henry A*, Manichaikul A*, Ramasamy A*, Loth DW*, Imboden M, Koch B, McArdle WL, Smith AV, Smolonska J, Sood A, Tang W, Wilk JB, Zhai G, Zhao JH, Aschard H, Burkart KM, Curjuric I, Eijgelsheim M, Elliott P, Gu X, Harris TB, Janson C, Homuth G, Hysi PG, Liu JZ, Loehr LR, Lohman K, Loos RJF, Manning AK, Marciante KD, Obeidat M, Postma DS, Aldrich MC, Brusselle GG, Chen T-H, Eiriksdottir G, Franceschini N, Heinrich J, Rotter JI, Wijmenga C, Williams OD, Bentley AR, Hofman A, Laurie CC, Lumley T, Morrison AC, Joubert BR, Rivadeneira F, Couper DJ, Kritchevsky SB, Liu Y, Wjst M, Wain LV, Vonk JM, Uitterlinden AG, Rochat T, Rich SS, Psaty BM, O’Connor GT, North KE, Mirel DB, Meibohm B, Launer LJ, Khaw K-T, Hartikainen A-L, Hammond CJ, Gläser S, Marchini J, Kraft P, Wareham NJ, Völzke H, Stricker BHC, Spector TD, Probst-Hensch NM, Jarvis D, Jarvelin M-R, Heckbert SR, Gudnason V, Boezen HM, Barr RG, Cassano PA†, Strachan DP†, Fornage M†, Hall IP†, Dupuis J†, Tobin MD†, and London SJ†. Genome-wide joint meta-analysis of SNP and SNP­ by-smoking interaction identifies novel loci for pulmonary function. PLoS Genetics. 2012; 8(12): e1003098. *These authors contributed equally to this work. †These authors jointly directed the work.

Bentley AR and Rotimi CN. Interethnic Variation in Lipid Profiles: Implications for Under- identification of African-Americans at-risk for Metabolic Disorders. Expert Review of Endocrinology and Metabolism. 2012 Nov; 7(6): 659-69.

Adeyemo A, Bentley AR [co-first author], Meilleur KG, Doumatey AP, Chen G, Zhou J, Shriner D, Huang H, Herbert A, Gerry NP, Christman MF, Rotimi CN. Transferability and Fine Mapping of genome-wide associated loci for lipids in African Americans. BMC Med Genet. 2012 Sep; 13(1): 88.

Bentley AR, Doumatey AP, Chen G, Huang H, Zhou J, Shriner D, Jiang C, Zhang Z, Liu G, Fasanmade O, Johnson T, Oli J, Okafor G, Eghan BA Jr, Agyenim-Boateng K, Adeleye J, Balogun W, Adebamowo C, Amoah A, Acheampong J, Adeyemo A, Rotimi CN. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association.Int J Nephrol. 2012: 748984

Wilk JB, Shrine NRG, Loehr LR, Zhao JH, Manichaikul A, Lopez LM, Smith AV, Heckbert SR, Smolonska J, Tang W, Loth DW, Curjuric I, Hui J, Cho MH, Latourelle JC, Henry AP, Aldrich M, Bakke P, Beaty TH, Bentley AR, Borecki IB, Brusselle GG, Burkart KM, Chen T, Couper D, Crapo JD, Davies G, Dupuis J, Franceschini N, Gulsvik A, Hancock DB, Harris TB, Hofman A, Imboden M, James AL, Khaw K, Lahousse L, Launer LJ, Litonjua A, Liu Y, Lohman KK, Lomas DA, Lumley T, Marciante KD, McArdle WL, Meibohm B, Morrison AC, Musk AW, Myers RH, North KE, Postma DS, Psaty BM, Rich SS, Rivadeneira F, Rochat T, Rotter JI, Soler Artigas M, Starr JM, Uitterlinden AG, Wareham NJ, Wijmenga C, Zanen P, Province MA, Silverman EK, Deary IJ, Palmer LJ, Cassano PA, Gudnason V, Barr RG, Loos RJF, Strachan DP, London SJ, Boezen HM, Probst-Hensch N, Gharib SA, Hall IP, O’Connor GT, Tobin MD, Stricker BH. Genome wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med. 2012 Oct 1; 186(7):622-32

Chen G, Yuan A, Zhou Y, Chen W, Bentley AR, Shriner D, Adeyemo A, Rotimi CN. Simultaneous Analysis of Common and Rare Variants in Complex Traits: Application to SNPs (SCARVAsnp). Bioinform Biol Insights. 2012; 6: 177-185.

Chen G, Bentley A, Adeyemo A, Shriner D, Zhou J, Doumatey A, Huang H, Ramos E, Erdos M, Gerry N, Herbert A, Christman M, Rotimi CN. Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. Hum Mol Gen. 2012; 21(20):4530-6.

Chen G, Yuan A, Zhou J, Bentley AR, Adeyemo A, Rotimi C. Simple F test reveals Gene-Gene interactions in Case-Control Studies. Bioinform Biol Insights. 2012; 6: 169-176.

Bentley AR, Kritchevsky SB, Harris TB, Newman AB, Bauer DC, Meibohm B, Clark AG, Cassano PA; for the Health, Aging, Body Composition Study. Genetic variation in antioxidant enzymes and lung function. Free Radic Biol Med. 2012 May 1; 52 (9): 1577-83.

Bentley AR, Kritchevsky S, Harris T, Holvoet P, Jensen R, Crapo R, Newman A, Bauer D, Lee JS, Tolley E, Yende S, Cassano PA, for the Health ABC Study. Dietary Antioxidants and FEV1Decline: the Health Aging and Body Composition Study. Eur Respir J. 2012 Apr;39(4):979­ 84.

Chen G, Ramos E, Adeyemo A, Shriner D, Zhou J, Doumatey AP, Huang H, Erdos MR, Gerry NP, Herbert A, Bentley AR, Xu H, Charles BA, Christman MF, Rotimi CN. UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur J Hum Genet. 2012 Apr; 20(4):463-8.

Yuan A, Chen G, Zhou Y, Bentley A, Rotimi C. A novel approach for the simultaneous analysis of common and rare variants in complex traits. Bioinform Biol Insights. 2012; 6: 1-9.

Doumatey AP, Bentley AR, Zhou J, Huang H, Adeyemo A, Rotimi CN. Paradoxical Hyperadiponectinemia is Associated with the Metabolically Healthy Obese (MHO) Phenotype in African Americans. J Endocrinol Metab. 2012; 2(2): 51-65.

Bentley AR, Raiszadeh F, Stover PJ, Hunter DJ, Hankinson SE, Cassano PA. No association between cSHMT genotypes and risk of breast cancer in the Nurses’ Health Study. Eur J Clin Nutr 2010; 64(1): 108-110.

Bentley AR, Emrani P, Cassano PA. Genetic Variation and Gene Expression in Antioxidant-Related Enzymes and Risk of Chronic Obstructive Pulmonary Disease: A Systematic Review. Thorax2008; 63 (11): 956-61.

Last updated: April 18, 2019