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NIH Intramural Sequencing Center
NIH Intramural Sequencing Center
NIH Intramural Sequencing Center
A.B. Washington University in St. Louis
Ph.D. Case Western Reserve University
Dr. James Thomas is the director of the NIH Intramural Sequencing Center. He oversees the importation and use of DNA sequencing technologies, protocols and analyses, ensuring that NIH investigators have access to cutting-edge DNA sequencing methods and specialized genomics protocols to meet their research needs.
Dr. James Thomas obtained his A.B. in biology from Washington University in St. Louis and completed his doctoral work in the Department of Genetics at Case Western Reserve University. In 1997, Dr. Thomas joined the NHGRI as a postdoctoral fellow and began his research in the emerging field of comparative genomics. Dr. Thomas went on to be an assistant professor in the Department of Human Genetics at the Emory University School of Medicine before returning to NHGRI and the NIH Intramural Sequencing Center in 2011.
Dr. James Thomas is the director of the NIH Intramural Sequencing Center. He oversees the importation and use of DNA sequencing technologies, protocols and analyses, ensuring that NIH investigators have access to cutting-edge DNA sequencing methods and specialized genomics protocols to meet their research needs.
Dr. James Thomas obtained his A.B. in biology from Washington University in St. Louis and completed his doctoral work in the Department of Genetics at Case Western Reserve University. In 1997, Dr. Thomas joined the NHGRI as a postdoctoral fellow and began his research in the emerging field of comparative genomics. Dr. Thomas went on to be an assistant professor in the Department of Human Genetics at the Emory University School of Medicine before returning to NHGRI and the NIH Intramural Sequencing Center in 2011.
Loftus SK, Gillis MF, Lundh L, Baxter LL, Wedel JC, Watkins-Chow DE, Donovan FX; NISC Comparative Sequencing Program; Sergeev YV, Oetting WS, Pavan WJ, Adams DR. Haplotype-based analysis resolves missing heritability in oculocutaneous albinism type 1B. Am J Hum Genet. 2023 Jul 6;110(7):1123-1137. doi: 10.1016/j.ajhg.2023.05.012. Epub 2023 Jun 15.
Grimm SA, Shimbo T, Takaku M, Thomas JW, Auerbach S, Bennett BD, Bucher JR, Burkholder AB, Day F, Du Y, Duncan CG, French JE, Foley JF, Li J, Merrick BA, Tice RR, Wang T, Xu X; NISC Comparative Sequencing Program; Bushel PR, Fargo DC, Mullikin JC, Wade PA. DNA methylation in mice is influenced by genetics as well as sex and life experience. Nat Commun. 2019 Jan 18;10(1):305. doi: 10.1038/s41467-018-08067-z.
Kalaskar VK, Alur RP, Li LK, Thomas JW, Sergeev YV, Blain D, Hufnagel RB, Cogliati T, Brooks BP. High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma. Hum Mutat. 2020 Mar;41(3):678-695. doi: 10.1002/humu.23954. Epub 2019 Dec 9.
Conlan S, Thomas PJ, Deming C, Park M, Lau AF, Dekker JP, Snitkin ES, Clark TA, Luong K, Song Y, Tsai YC, Boitano M, Dayal J, Brooks SY, Schmidt B, Young AC, Thomas JW, Bouffard GG, Blakesley RW; NISC Comparative Sequencing Program; Mullikin JC, Korlach J, Henderson DK, Frank KM, Palmore TN, Segre JA. Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae. Sci Transl Med. 2014 Sep 17;6(254):254ra126. doi: 10.1126/scitranslmed.3009845.
Horton BM, Hudson WH, Ortlund EA, Shirk S, Thomas JW, Young ER, Zinzow-Kramer WM, Maney DL. Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1443-8. doi: 10.1073/pnas.1317165111. Epub 2014 Jan 13.
Thomas, J.W., Cáceres, M., Lowman, J.J., Morehouse, C.B., Short, M.E., Baldwin, E.L., Maney,D.L., Martin, C.L. The chromosomal polymorphism linked to variation in social behavior in the white-throated sparrow (Zonotrichia albicollis) is a complex rearrangement and suppressor of recombination. Genetics, 179:1455-1468. 2008.
Cáceres, M., NISC Comparative Sequencing Program, Sullivan, R.T, Thomas, J.W. A recurrent inversion on the eutherian X chromosome. Proc. Natl. Acad. Sci. USA, 104:18571-18576. 2007.
Thomas, J.W., Touchman, J.W., Blakesley, R.W., Bouffard, G.G., Beckstrom-Sternberg, S.M., Margulies, E.H., Blanchette, M., Siepel, A.C., Thomas, P.J., McDowell, J.C., Maskeri, B., Hansen, N.F., Schwartz, M.S. Weber, R.J., Kent, W.J., Karolchik, D., Bruen, T.C., Bevan, R. Cutler, D.J., Schwartz, S., Elnitski, L., Idol, J.R., Prasad, A.B., Lee-Lin, S.-Q., Benjamin, B., Cariaga, K., Brinkley, C.P., Brooks, S.Y., Granite, S., Guan, X., Gupta, J., Haghighi, P., Ho, S.L., Huang, M.C., Karlins, E., Laric, P.L., Legaspi, R., Lim, M.J., Maduro, Q.L., Masiello, C.A., Mastrian, S.D., McCloskey, J.C., Pearson, R., Stantripop, S., Tiongson, E.E., Tran, J.T., Tsurgeon, C., Vogt, J.L., Walker, M.A., Wetherby, K.D., Wiggins, L.S., Young, A.C., Zhang, L-H., Osoegawa, K., Zhu, B., Zhao, B., Shu, C.L., de Jong, P.J., Lawrence, C.E., Smit, A.F., Chakravarti, A., Haussler, D., Green, P., Miller, W., Green, E.D. Comparative analyses of multi-species sequences from targeted genomic regions. Nature, 424:788-793. 2003.
Thomas, J.W., Prasad, A.B., Summers, T.J., Lee-Lin, S.Q., Maduro, V.V.B., Idol, J.R., Ryan, J.F., Thomas, P.J., McDowell, J.C., Green, E.D. Parallel construction of orthologous sequence-ready clone contig maps in multiple species. Genome Research, 12:1277-1285. 2002.
Thomas, J.W., LaMantia, C.L., Magnuson, T. X-ray-induced mutations in mouse embryonic stem cells. Proc. Natl. Acad. Sci. USA95:1114-1119.1998.
Last updated: October 1, 2024
