NHGRI logo
Senior Investigator Laboratory of Cardiovascular Regenerative Medicine

National Heart, Lung and Blood Institute

Adjunct Investigator

Office of the Clinical Director


M.D. University of Heidelberg 1993


Manfred Boehm received his M.D. in 1993 from the University of Heidelberg, Germany, and did his residency in internal medicine at the Franz-Volhard-Clinic in Berlin. Before arriving at the NHLBI, he was a research fellow at the Max Delbrück Center for Molecular Medicine, Berlin, from 1996 to 1997, and the University of Michigan, Ann Arbor, from 1997 to 1999. He joined the NHLBI as a research fellow in 1999 and has been an investigator since 2003. Dr. Boehm received a Foundation for Advanced Education in the Sciences Award for Research Excellence from the NIH.

Dr. Boehm has authored numerous original scientific articles, reviews, and book chapters. He serves on the editorial boards of Trends in Cardiovascular Medicine, ISRN Stem Cells, Atherosclerosis, and Journal of Molecular Medicine. Dr. Boehm holds two patents, has participated in cooperative research and development agreements with biotechnology companies and has several active clinical protocols.


Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St Hilaire C, Boehm M. Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J. Clin. Invest, 120(1):303-14. 2010. [PubMed]

St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA, Boehm M. NT5E mutations and arterial calcifications. N. Engl. J. Med, 364(5):432-42. 2011. [PubMed]

Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM. Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med 370(10):911-20. 2014. [PubMed]

Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M. TGF- β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med, 6(227):227ra34. 2014. [PubMed]

Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Montealegre Sanchez GA, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CC, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S. Activated STING in a vascular and pulmonary syndrome. N Engl J Med, 371(6):507-18. 2014. [PubMed]

Last updated: September 13, 2017