Ostrander Group
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Elaine A. Ostrander, Ph.D.

Chief & NIH Distinguished Investigator, Cancer Genetics and Comparative Genomics Branch
Head, Comparative Genetics Section

Selected Publications

Dunaway M, Ostrander EA. (1993). Local domains of supercoiling activate a eukaryotic promoter in vivo. Nature 361:746-8. 1993. [PubMed]

Langston AA, Malone KE, Thompson JD, Daling JR, Ostrander EA. (1996). BRCA1 mutations in a population-based sample of young women with breast cancer. N Engl J Med, 334:137-42. 1996. [PubMed]

Stanford JL, Just JJ, Gibbs M, Wicklund KG, Neal CL, Blumenstein BA, Ostrander EA. Polymorphic repeats in the androgen receptor gene: molecular marker of prostate cancer risk. Cancer Res, 57:1194-8. 1997. [PubMed]

Gibbs M, Stanford JL, McIndoe RA, Jarvik GP, Kolb S, Goode EL, Chakrabarti L, Schuster EF, Buckley VA, Miller EL, Brandzel S, Li S, Hood L, Ostrander EA. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet, 64:776-87. 1999. [PubMed]

Guyon R, Lorentzen TD, Hitte C, Kim L, Cadieu E, Parker HG, Quignon P, Lowe JK, Renier C, Gelfenbeyn B, Vignaux F, DeFrance HB, Gloux S, Mahairas GG, André C, Galibert F, Ostrander EA. A 1-Mb resolution radiation hybrid map of the canine genome. Proc Natl Acad Sci U S A, 100:5296-301. 2003. [PubMed]

Lingaas F, Comstock KE, Kirkness EF, Sørensen A, Aarskaug T, Hitte C, Nickerson ML, Moe L, Schmidt LS, Thomas R, Breen M, Galibert F, Zbar B, Ostrander EA. A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd Dog. Hum Mol Genet, 12:3043-53. 2003. [PubMed]

Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. Genetic structure of the purebred domestic dog. Science, 304:1160-4. 2004. [PubMed]

Mosher DS, Quignon P, Bustamante CD, Sutter NB, Mellersh CS, Parker HG, Ostrander EA. A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genetics 5, 3(5):e79. 2007. [PubMed]

Sutter NB, Bustamante CD, Chase K, Gray MM, Zhao K, Zhu L, Padhukasahasram B, Karlins E, Davis S, Jones PG, Quignon P, Johnson GS, Parker HG, Fretwell N, Mosher DS, Lawler DF,  Satyaraj E, Nordborg M, Lark KG, Wayne RK, Ostrander EA. A single IGF1 allele is a major determinant of small size in dogs . Science, 316(5821):112-5. 2007. [PubMed]

Parker HG, vonHoldt BM, Quignon P, Margulies EH, Shao S, Mosher DS, Spady TC, Elkahloun A, Cargill M, Jones PG, Maslen CL, Acland GM, Sutter NB, Kuroki K, Bustamante CD, Wayne RK, Ostrander EA. An expressed Fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs. Science, 325:995-8. 2009. [PubMed]

Suuriniemi, M, Aaliu I, Schaid DJ, Johanesson B, McDonell SK, Iwasaki L., Stanford JL, Ostrander EA. Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. Cancer Epi Biomarkers, 16(4):809-14. 2007. [PubMed]

Schaid DJ, Stanford JL, McDonnell, SK, Suuriniemi M, McIntosh L, Karyadi DM, Carlson E, Deutsch K., Janer M., Hood L. Ostrander E.A. Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q. Hum. Genetics, 121:729-35. 2007. [PubMed]

Parker HG, Kukekova AV, Akey DT, Goldstein O, Kirkness E F, Baysac KC, Mosher DS, Aguirre GD, Acland GM, Ostrander EA Breed relationships facilitate fine mapping studies: A 7.8 Kb deletion cosegregates with collie eye anomaly across multiple dog breeds. Genome Res, 17:1562-1571. 2007. [PubMed]

Holt SK, Karyad DM, Kwon EM, Stanford JL, Nelson PS, Ostrander EA. Association of megalin genetic polymorphisms with prostate cancer risk and prognosis. Clinical Cancer Research, 15:3823-31. 2008. [PubMed]

FitzGerald LM, Kwon EM, Koopmeiners JS, Salinas CA, Stanford JL, Ostrander EA. Analysis of recently identified prostate cancer susceptibility loci in a population-based study: Associations with family history and clinical features. Clinical Cancer Research, 5:3231-7. 2009. [PubMed]

Parker HG, Von Holdt BM, Quignon P, Margulies EH, Shao S, Mosher DS, Spady TC, Elkahloun A, Cargill M, Jones PG, Maslen CL, Acland GM, Sutter NB, Kuroki K, Bustamante CD, Wayne RK, Ostrander EA. An expressed Fibroblast Growth Factor 4 (fgf4) retrogene is associated with breed-defining chondrodysplasia in the domestic dog. Science, 325:995-8. 2009. [PubMed]

Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, vonHoldt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed by variants in three genes. Science, 326:150-3. 2009. [PubMed]

Boyko AR, Quignon P, Li L, Schoenebeck JJ, Degenhardt JD, Lohmueller KE, Zhao K, Brisbin A, Parker HG, vonHoldt BM, Cargill M, Auton A, Reynolds A, Elkahloun AG, Castelhano M, Mosher DS, Sutter NB, Johnson GS, Novembre J, Hubisz MJ, Siepel A, Wayne RK, Bustamante CD, Ostrander EA. A simple genetic architecture underlies morphologic variation in dogs. PLoS Biol, 8:e1000451. 2010. [PubMed]

vonHoldt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P, Degenhardt JD, Boyko AR, Earl DA, Auton A, Reynolds A, Bryc K, Brisbin A, Knowles JC, Mosher DS, Spady TC, Elkahloun A, Geffen E, Pilot M, Jedrzejewski W, Greco C, Randi E, Bannasch D, Wilton A, Shearman J, Musiani M, Cargill M, Jones PG, Qian Z, Huang W, Ding ZL, Zhang YP, Bustamante CD, Ostrander EA, Novembre J, Wayne RK. Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature, 464: 898-902. 2010. [PubMed

Kwon EM, Salinas CA, Kolb S, Fu R, Feng Z, Stanford JL, Ostrander EA. Genetic polymorphisms in inflammation pathway genes and prostate cancer risk. Cancer Epidemiol Biomarkers Prev, 20:923-33. 2011. [PubMed]

Shearin AL, Hedan B, Cadieu E, Erich SA, Schmidt EV, Faden DL, Cullen J, Abadie J, Kwon EM, Gröne A, Devauchelle P, Rimbault M, Karyadi DM, Lynch M, Galibert F, Breen M, Rutteman GR, André C, Parker HG, Ostrander EA. The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. Cancer Epidemiol Biomarkers Prev, 21:1019-27. 2012. [PubMed]

Schoenebeck JJ, Hutchinson SA, Byers A, Beale HC, Carrington B, Faden DL, Rimbault M, Decker B, Kidd JM, Sood R, Boyko AR, Fondon JW 3rd, Wayne RK, Bustamante CD, Ciruna B, Ostrander EA. Variation of BMP3 contributes to dog breed skull diversity. PLoS Genet, 8:e1002849. 2012. [PubMed]

Ostrander EA. Franklin H. Epstein Lecture. Both ends of the leash--The human links to good dogs with bad genes. New Engl J Med, 367:636-46. 2012. [PubMed]

Rimbault M, Beale HC, Schoenebeck JJ, Hoopes BC, Allen JJ, Gilroy-Glynn P, Wayne RK, Sutter NB, Ostrander EA.  Derived variants at six genes explain nearly half of size reduction in domestic dogs.  Genome Res., 23:1985-95. 2013. [PubMed Central]

Rebbeck TR, Devesa SS, Chang B-L, Bunker CH, Cheng I, Cooney KA, Eeles R, for The UKGPCS Coordinating Group and Collaborators, Fernandez P, Giri VN, Gueye SM, Haiman CA, Henderson BE, Heyns C, Hu JJ, Ingles SA, Isaacs W, Jalloh M, John, EM, Kibel AS, Kidd, LR, Layne P, Leach RJ, Neslund-Dudas C, Okobia MN, Ostrander EA, Park JY, Patrick AL, Phelan C, Ragin C, Roberts R, Rybicki B, Stanford JL, Strom S, Thompson IM, Witte J, Xu J, Yeboah E, Hsing, AW, Zeigler-Johnson C. Global patterns of prostate cancer incidence, aggressiveness and mortality in men of African descent. Prostate Cancer 2013:560857. 2013.

Karyadi DM, Karlins E, Decker B, vonHoldt BM, Carpintero-Ramirez G, Parker HG, Wayne RK, Ostrander EA. A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit. PLoS Genetics 9:e1003409; 2013.  [PubMed]

Freedman A, Schweizer RM, Gronau I, Han Enujung, Vecchyo DOD, Silva P, Galaverni M, Zhenxin F, Marx P, Lorente-Galdos B, Beale H, Ramirez O, Hormozdiari F, Alkan C, Vilà C, Squire K, Geffern, E, Kusak J, Boyko AR, Parker H, Lee C, Tadigotla V, Siepel A, Bustamante C, Harkins T, Nelson SF, Ostrander EA, Marques-Bonet T, Wayne RK, Novembre J. Genome sequencing highlights the dynamic early history of dogs. PLoS Genetics, Jan:10(1):e1004016. 2014. [PubMed]

Decker B, Parker HG, Dhawan D, Kwon EM, Karlins E, Davis BW, Ramos-Vara JA, Bonney PL, McNiel EA, Knapp DW, Ostrander EA. Homologous mutation to human BRAF V600E is common in naturally occurring canine bladder cancer-evidence for a relevant model system and urine-based diagnostic test. Mol Canc Res 13(6):993-1002. 2015. [PubMed]

Bemdt SI, Wang Z, Yeager M, Alavanga, MC, Albanes, D, Amundadottir L, Andriole G,  Freeman LB, Campa D, Cancel-Tassin G, Canzian F, Cornu J-N, Cussenot O, Diver WR,  Gapstur SM, Grönberg H, Haiman CA, Henderson B, Hutchinson A, Hunter DJ, Key TJ, Kolb S, Koutros S, Kraft P, Le Marchand L, Lindström S, Machiela MJ, Ostrander EA,  Riboli E, Schumacher F,  Siddiq A,  Stanford JL, Stevens VL, Travis RC, Tsilidis KK, Virtamo J, Weinstein S, Wilkund F, Xu J, Zheng SL, Yu K, Wheeler W, Zhang H, African Ancestry Prostate Cancer GWAS Consortium, Sampson J,  Black A, Jacobs K, Hoover RN, Tucker M, Chanock SJ. Two susceptibility loci identified for prostate cancer aggressiveness. Nat Comm. May 5;6:6889. doi: 10.1038/ncomms7889.  2015. [PubMed]

Decker B, Davis BW, Rimbault M, Long AH, Karlins E., Jagannathan, V, Reiman, R, Parker HG, Drogemuller, C, Corneveaux, JJ, chapman, ES, Trent JM, Leeb, T, Huentelman JM, WayneRK, Karyadi DM, Ostrander EA. Comparison against 186 canid whole genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor. Genome Res. pii: gr.190314.115. 2015. [PubMed]

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Last Updated: October 21, 2015