Elaine A. Ostrander, Ph.D.

Chief & NIH Distinguished Investigator, Cancer Genetics Branch
Head, Comparative Genetics Section

Selected Publications:

Sutter, N.S., Eberle, M.A., Parker, H.G., Pullar, B. J., Kirkness, E.F., Kruglyak, L., Ostrander E.A. Extensive and breed specific linkage disequilibrium in Canis familiaris. Genome Res, 12:2388-96. 2004. [PubMed]

Ostrander, E.A., and Wayne, R.K. The canine genome. Genome Research, (12):1706-16. 2005. [PubMed]

Malone, K.E., Daling, J.R., Doody, D.R., Hsu, L., Bernstein, L., Coates, R.J, Marchbanks, P.A., Simon, M.S., McDonald, J.A. Norman, S.A. Strom, B.L., Burkman, R.T., Ursin, G., Deapen, D., Weiss, L.K., Folger, S.F., Madeoy J.J., Friedrichsen, D.F., Suter, N.M., Humphrey, M.C,. Spirtas R., Ostrander E.A. Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. Cancer Research, 66:8297-308. 2006. [PubMed]

Khanna, C., Lindblad-Toh, L., Vail, D., London, C., Bergman, P., Barber, L., Breen, M., Kitchell, B., McNeil, E., Modiano, J.F., Niemi, S., Comstock, K.E., Ostrander, E., Westmoreland, S., Withrow S. The dog as a cancer model. Nature Biotechnol, 24:1065-6. 2006. [PubMed]

Suuriniemi, M., Aaliu I., Schaid D.J., Johanesson, B., McDonell, S.K., Iwasaki L., Stanford J.L., Ostrander E.A. Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. Cancer Epi Biomarkers, 16(4):809-14. 2007. [PubMed]

Sutter, N.B., Bustamante, C.D., Chase K., Gray M.M.., Zhao K., Zhu L., Padhukasahasram, B., Karlins, E., Davis, S., Jones, P.G., Quignon, P., Johnson, G.S., Parker, H.G., Fretwell, N., Mosher, D.S., Lawler, D.F., Satyaraj, E., Nordborg, M., Lark, K.G., Wayne, R.K., Ostrander E.A. A Single IGF1 Allele is a Major Determinant of Small Size in Dogs . Science, 316(5821):112-5. 2007. [PubMed]

Mosher D., Quignon, P., Sutter, N.B., Mellersh C.S., Ostrander E.A. (2007). A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genetics 5, 3(5):e79. 2007. [PubMed]

Schaid D.J., Stanford J.L., McDonnell, S.K., Suuriniemi M., McIntosh, L., Karyadi, D.M., Carlson E., Deutsch K., Janer M., Hood L. Ostrander E.A. Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q. Hum. Genetics, 121:729-35. 2007. [PubMed]

Parker H.G., Kukekova A.V., Akey D.T., Goldstein O., Kirkness E. F., Baysac K.C., Mosher D.S., Aguirre G.D. Acland G.M., Ostrander E.A. Breed relationships facilitate fine mapping studies: A 7.8 Kb deletion cosegregates with collie eye anomaly across multiple dog breeds. Genome Research, 17:1562-1571. 2007. [PubMed]

Wayne, R.K., Ostrander E.A. Lessons learned from the dog genome. Trends In Genetics, 23:557-67. 2007. [PubMed]

Johanneson B., McDonnell S.K., Karyadi D.M., Hebbring, S.J., Wang L., Deutsch K., McIntosh L., Kwon E.M., Suuriniemi M., Stanford J.L., Schaid D.J., Ostrander E.A., Thibodeau S.N. Fine-mapping of hereditary prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. Human Genetics, 123:65-75. 2007. [PubMed]

Jones P., Chase K., Martin A., Ostrander E.A. Lark K.G. SNP-Based association mapping of dog stereotypes. Genetics, 179:1033-44. 2008. [PubMed]

Holt S.K., Karyad D.M., Kwon E.M., Stanford J.L., Nelson P.S., Ostrander E.A. Association of megalin genetic polymorphisms with prostate cancer risk and prognosis. Clinical Cancer Research, 15:3823-31. 2008. [PubMed]

FitzGerald L.M., Kwon E.M., Koopmeiners J.S., Salinas C.A., Stanford J.L., Ostrander E.A. Analysis of recently identified prostate cancer susceptibility loci in a population-based study: Associations with family history and clinical features. Clinical Cancer Research, 5:3231-7. 2009. [PubMed]

Stanford J.L., FitzGerald L.M., McDonnell S.K., Carlson E.E., McIntosh L.M., Deutsch K., Hood L., Ostrander E.A., Schaid D.J. Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage. Human Molecular Genetics, 18:1839-1848. 2009. [PubMed]

Parker H.G., Von Holdt B.M., Quignon P., Margulies E.H., Shao S., Mosher D.S., Spady T.C. Cargill M., Jones, P.G., Maslen, C.L., Acland, G.M., Sutter, N.B., Cook J.L., Bustamante, C.D., Wayne, R.K., Ostrander E.A. Wayne R.K., Ostrander E.A. An expressed Fibroblast Growth Factor 4 (fgf4) retrogene is associated with breed-defining chondrodysplasia in the domestic dog. Science, 325:995-8. 2009. [PubMed]

Cadieu, E., Neff, M., Quignon, P., Walsh, K., Chase, K., Parker, H.G., VonHoldt, B.M., Rhue, A., Boyko A., Byers A., Wong, A., Mosher D.S., Elkahloun, A.G., Spady, T.C. Andre, C., Lark, K.G., Cargil M., Bustamante, C.D., Wayne, R.K., Ostrander E.A. Coat variation in the domestic dog is governed by variants in three genes Science, 326:150-3. 2009. [PubMed]

Ostrander, E.A., Huson, H.J., Ostrander, G.K. Genetics of athletic performance. Annual Reviews of Genomics and Human Genetics, 10:407-29. 2009. [PubMed]

Udler M.S., Meyer K.B., Pooley K.A., Karlins E., Struewing J.P., Zhang J., Doody D.R., Macarthur S., Tyrer J., Pharoah P.D., Luben R.; SEARCH Collaborators, Bernstein L., Kolonel L.N., Henderson B.E., Le Marchand L., Ursin G., Press M.F., Brennan P., Sangrajrang S., Gaborieau V., Odefrey F., Shen C.Y., Wu P.E., Wang H.C., Kang D., Yoo K.Y., Noh D.Y., Ahn S.H., Ponder B.A., Haiman C.A., Malone K.E., Dunning A.M., Ostrander E.A., Easton D.F. FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation. Human Molecular Genetics, 18:1692-703. 2009. [PubMed]

Eeles R.S., Kote-Jarai Z., Al Olama A.A., Giles G.G., Guy M., Seven G., Muir K., Hopper J.L., Henderson B.E., Haiman C.A., Schleutker J., Hamdy F.C., Neal D.E., Donovan J.L., Stanford J.W., Ostrander E.A. Ingles S.A. John E.M., Thibideau S.N., Schaid D., Park J, Spurdle A., et al.. Identification of seven novel prostate cancer susceptibility loci through a genome-wide association study. Nature Genetics, 41:1116-21. 2009. [PubMed]

Zhu, Y., Steven, R.G., Hoffman, A., FitzGerald, L.M., Kwon, E.M., Ostrander E.A., Davis S., Zheng, T., Stanford, J.L. Testing the circadian gene hypothesis in prostate cancer: A population-based case control study. Cancer Research, 69:9315-22. 2009. [PubMed].


Parker, H.G., Sutter, N.B., Ostrander E.A.: Understanding genetic relationship among purebred dogs: The PhyDo Project. In: E.A. Ostrander, K. Lindbland-Toh, Urs Giger, (eds). The Dog and Its Genome. Cold Spring Harbor Press. 2006.

Hitte C., Kirkness E.F., Ostrander, E.A. Galibert, F.: Survey sequencing and radiation hybrid mapping to construct comparative maps. In: W. Murphy (ed). Methods in Molecular Biology: Phylogenomics. Humana Press, 2006.

Ostrander E.A., and Wayne R.K. The Canine Genome. In: H. Sussman and M.A. Smit, (eds.) Genomes. Cold Spring Harbor Press. 275 pp. 2006.

Every dog has its day: An overview of the recent advances in canine genetics. In: C. Kole & Noelle E. Cockett (eds.). Genome Mapping in Animals. Springer-Verlag. [In Press]

Ostrander E.A., Parker, H.G., and Sutter N.B. Canine Genetics Facilitates Understanding of Human Biology. In: 2006 Stadler Symposium. St. Louis. 2006. [In Press].

Ostrander E.A. and Parker H.G. Human genetics and the canine system. In: F. Vogel, A. Motulsky, S, Antonarakis and M. Speicher. (eds.) Human Genetics: Principals and Approaches. 4th Edition. Springer Publishing. 2007 [In Press].

Ostrander, E.A., and Johannesson, B. Hormonal Carcinogenesis III. In: Li, J.J., and Li, S.A. (eds.) Springer-Verlag. 2007. [In Press].

Lindblad-Toh, K. and Ostrander, E.A. Canine genetics and genome variation. In: S. Gabriel, J.C. Stephens and M. Weiner (eds.) Genetic Variation: A Laboratory Manual. Cold Spring Harbor Press. 2007. [In Press].

Ostrander E.A. and Karyadi, D.M. Genetic factors: Finding cancer susceptibility genes. In: Abeloff M.D., Armitage J.O, Niederhuber J.E., Kastan M.B. and McKenna W.G. (eds): Abeloff's Clinical Oncology, 4th ed. Elsevier Science, Philadelphia PA, pp. 193-205. 2008.

Hitte C., Kirkness E.F., Ostrander E.A. Galibert F. Survey sequencing and radiation hybrid mapping to construct comparative maps. In: Methods in Molecular Biology: Phylogenomics, Editor: W. Murphy. Humana Press. Series Editor: J. Walker. pp. 65-77. 2008

Ostrander, E.A., and Johanneson, B. Prostate cancer susceptibility loci: Finding the genes. In: Hormonal Carcinogenesis V. Li, J.J., Li, S.A., Mohla, S., Rochefort, H., Maudelonde, T., (eds.) Volume 617, Springer-Verlag, New York pp. 179-190. 2008.

Potter, J. D. and Lindor N.M. Genetics of Colorectal Cancer; in Cancer Genetics, Series Editor: Ostrander, E,A., Springer Science + Business Media and Humana Press, New York, NY. 2008.

Mosher, D.S., Spady, T.C., Ostrander E.A. Every dog has its day: An overview of the recent advances in canine genetics. In: Genome Mapping and Genomics in Animals, Volume 3, Eds: C. Kole & N. E. Cockett, Springer-Verlag Berlin Heidelberg, New York, Tokyo Chapter 8, pp. 231-256. 2009.

Ostrander E.A., Parker, H.G., and Sutter N.B. Canine Genetics Facilitates Understanding of Human Biology in: 2006 Stadler Symposium. St. Louis. 2009. [In Press]

Ostrander E.A. and Parker H.G. Human genetics and the canine system in: Human Genetics: Principals and Approaches 4th Edition, Eds: F. Vogel, A. Motulsky, S, Antonarakis and M. Speicher. Springer Publishing. 2009. [In Press]

Welcsh, P. (Editor). The Role of Genetics in Breast and Reproductive Cancers; in Cancer Genetics, Series Editor: Ostrander, E, A., Springer Science + Business Media and Humana Press, New York, NY. 2009. [In Press]

Top of page

Last Reviewed: November 12, 2010