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Sean Conlan, Ph.D.

Associate Investigator, Translational and Functional Genomics Branch
Microbial Genomics Section 

Selected Publications

Byrd AL, Deming C, Cassidy S, Harrison OJ, Conlans S, NISC Comparative Sequencing Program, Belkaid Y, Segre JA and Kong HH. Staphylococcal strain diversity modulates atopic dermatitis disease pathogenesis. [In Press]

Dekker BK, Lau AF, Dekker JP, Spalding CD, Sinaii N, Conlan S, Dodd LE, Henderson DK, Segre JA, Frank KM and Palmore TN. Perirectal colonization of healthcare personnel with multidrug resistant organisms. [In Press]

Chen M, Conlan S, Lau AF, Deming C, NISC Comparative Sequencing Program, Frank KM, Palmore TN and Segre JA. Whole genome sequencing overrules a suspected case of carbapenem-resistant Enterobacter cloacae transmission. [InPress]

Hardiman CA, Weingarten RA, Conlan S, Khil P, Dekker JP, Mathers AJ, Sheppard AE, Palmore TN, Segre JA and Frank KM. Horizontal transfer of carbapenemase-encoding plasmids and comparison with hospital epidemiology data. Antimicrob Agents Chemother, 60(8)4910-9. 2016. [PubMed]

Conlan S, Lau AF, NISC Comparative Sequencing Program, Palmore TN, Frank KM and Segre JA. Complete genome sequence of a Klebsiella pneumoniae carrying blaNDM-1 on a multidrug resistance plasmid. GenomeA, 4(4):e00664-16. 2016. [PubMed]

Conlan S, Park M, Deming C, Thomas PJ, Young AC, Coleman H, Sison C, NISC Comparative Sequencing Program, Weingarten RA, Lau AF, Dekker JP, Palmore TN, Frank KM and Segre JA. Plasmid dynamics in KPC-Positive Klebsiella pneumoniae during long-term patient colonization. MBio, 7(3):e00742-16. 2016. [PubMed]

Jo J-H, Deming C, Kennedy EA, Conlan S, Polley EC, Ng W-I, NISC Comparative Sequencing Program, Segre JA and Kong HH. Diverse human skin fungal communities in children converge in adulthood. J Invest Dermatol, 136(12):2356-2363.  2016.  [PubMed]

Hughes HY, Conlan SP, Lau AF, Dekker JP, Michelin AV, Youn JH, Henderson DK, Frank KM, Segre JA and Palmore TN. Detection and whole genome sequencing of carbapenemase-producing Aeromonas hydrophila from routine perirectal surveillance culture. JCM, 54(4):1167-70. 2016. [PubMed]

Tsai Y-C, Conlan S, Deming C, NISC Comparative Sequencing Program, Segre JA, Kong HH, Korlach J and Oh J. Resolving the complexity of human skin metagenomes using single molecule sequencing. MBio, 7(1):e01948-15. 2016. [PubMed]

Dotson GA, NISC Comparative Sequencing Program, Dekker JP, Palmore TN, Segre JA and Conlan S. Draft Genome Sequence of a KPC+ Sequence Type 111 Pseudomonas aeruginosa. GenomeA, 4(1):e01663-15. 2016. [PubMed]

Naik S, Bouladoux N, Linehan JL, Han S, Harrison OJ, Wilhelm C, Conlan S, Himmelfarb S, Byrd AL, Deming C, Quinones M, Brenchley JM, Kong HH, Tussiwand R, Murphy KM, Merad M, Segre JA and Belkaid Y. Commensal-dendritic-cell interaction specifies a unique protective skin immune signature. Nature, 520(7545):104-8. 2015. [PubMed]

Conlan S, Deming C, Tsai Y-C, Lau AF, Dekker JP, Korlach J and Segre JA. Complete Genome Sequence of a Klebsiella pneumoniae with Chromosomally Encoded Carbapenem Resistance and Colibactin Synthesis Loci. Genome A, 2(6):e01332-14. 2014. [PubMed]

Oh J, Bryd AL, Deming C, Conlan S, NISC Comparative Sequencing Program, Kong HH and Segre JA. The biogeography of the human skin metagenome reveals novel functional divergence defined by skin habitat and individual variation. Nature, 513(7520):59-64. 2014. [PubMed]

Conlan S, Thomas PJ, Deming C, Deming C, Park M, Lau AF, Dekker JP, Snitkin ES, Clark TA, Luong K, Song Y, Tsai Y-C, Boitano M, Dayal J, Brooks SY, Schmidt B, Young AC, Thomas JW, Bouffard GG, Blakesley RW, NISC Comparative Sequencing Program, Mullikin JC, Korlach J, Henderson DK, Frank KM, Palmore TN and Segre JA. Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae. Science Translational Medicine 6(254), 254ra126. 2014. [PubMed]

van Duin D, Perez F, Rudin SD, Cober E, Hanrahan J, Ziegler J, Webber R, Fox J, Mason P, Richter SS, Cline M, Hall GS, Kaye KS, Jacobs MR, Kalayjian RC, Salata RA, Segre JA, Conlan S, Evans S, Fowler VG and Bonomo RA. Surveillance of Carbapenem-Resistant Klebsiella pneumoniae: Tracking Molecular Epidemiology and Outcomes through a Regional Network. Antimicrob Agents Chemother, 58(7):4035-4041. 2014. [PubMed]

Curtis DS, Phillips AR, Callister SJ, Conlan S and McCue LA. SPOCS: software for predicting and visualizing orthology/paralogy relationships among bacterial genomes. Bioinformatics 29(20), 2641-42. 2013. [PubMed]

Findley K, Oh J, Yang J, Conlan S, Deming C, Meyer JA, Schoenfeld D, Nomicos E, Park M, NISC Comparative Sequencing Program, Kong HH, and Segre JA. Human skin fungal diversity. Nature, 498(7454):367-70. 2013. [PubMed]

Zelazny AM, Ding L, Goldberg JB, Mijares L, Conlan S, Conville PS, Stock F, Ballentine SJ, Olivier KN, Sampaio EP, Murray PR and Holland SM. Adaptability and persistence of the emerging pathogen Bordetella petrii. PLoS One, 8(6): e65102. 2013[PubMed]

Conlan S, Kong HH and Segre JA. Species-Level Analysis of DNA Sequence Data from the NIH Human Microbiome Project. PLoS One, 7(10):e47075. 2012. [PubMed]

Oh J, Conlan S, Polley E, Segre JA and Kong HH. Shifts in human skin and nares microbiota of healthy children and adults. Genome Med, 4(10):77. 2012. [PubMed]

Naik S, Bouladoux N, Salcedo R, Kastenmuller W, Deming C, Quinones M, Brown C, Koo L, Conlan S, Spencer S, Hall J, Dzutsev A, Trinchierir G, Segre JA and Belkaid Y. Compartmentalized control of skin immunity by resident commensals. Science, 337(6098):1115-9. 2012. [PubMed]

Conlan S, Mijares LA, NISC Comparative Sequence Program, Becker J, Blakesley RR, Bouffard GG, Brooks S, Gupta J, Gurson N, ParkM, Schmidt B, Thomas PJ, Young A, Otto M, Kong HH, Murray PR and Segre JA. Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates. Genome Biology, 13(7):R64. 2012. [PubMed]

The Human Microbiome Consortium. Structure, Function and Diversity of the Human Microbiome in an Adult Reference Population. Nature, 486(7402):207-14. 2012. [PubMed]

The Human Microbiome Consortium. A Framework for Human Microbiome Research. Nature, 486(7402):215-21. 2012. [PubMed]

Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, Nomicos E, Polley E, Komarow HD, NISC Comparative Sequence Program, Murray PR, Turner ML and Segre JA. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Research, 22(5):850-9. 2012). [PubMed]

Posted: December 13, 2016