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Genomics FAQ for Entry-level Nurses

American Association of Critical-Care Nurses (AACN) defines entry-level nurses as nurses who are preparing or practicing in an initial professional nursing degree.

Why is genomics important for nurses?

Clinical care is increasingly focusing on precision health. Precision healthcare refers to care that is delivered based upon the understanding of a person’s unique genomic information combined with lifestyle and social, economic, cultural, and environmental contexts and how these influence well-being and health outcomes. Over half of the world’s healthcare workforce are nurses. No other profession interfaces more directly with patients and for longer periods of time than nurses.

Nurses are trained to:

  • Care for the whole person and consider the influence of biopsychosocial interactions on health outcomes.
  • Care for patients of all ages on a continuum of health and illness that is influenced by genomics and the environment.
  • Obtain a family history to assist with early screening detection of genetic conditions or health habits that may affect a patient’s genome.
  • Help families find answers to rare and common conditions by directing them to valid sources of information.
  • Educate patients and families about genomics-informed targeted interventions for cancer, infections, and pharmacotherapy.

Genomics plays a role in every aspect of nursing, which includes providing one-on-one care, treating entire populations, teaching the next generation of nurses, or making discoveries in the lab.

Expert Commentary


Sarah Dewell, Ph.D., MSc, RN
Assistant Professor
University of Northern British Columbia


Why should nurses understand basic genomic principles?

Genomic principles form the foundation for disease pathophysiology

  • Genomics underlies all diseases
  • Genomics contributes to our understanding of the mechanisms of disease


Genomics principles influence clinical actions

  • Genomics knowledge is essential for supporting clinical practice and potential interventions (e.g., newborn screening tests).
  • Obtaining genomic information about a patient can change recommendations for prevention and screening (e.g., recommendations for annual MRI with elevated breast cancer risk)
  • Genomics affects pharmacokinetics and pharmacodynamics, meaning that it affects drug selection and/or dose (e.g., antidepressants, anticoagulants).


Understanding genomic principles facilitates communication with patients and family members and supports genomics-informed care

  • Patients often need help understanding how genomics influences their health and the health of their family members.
  • Effective patient and family education requires foundational knowledge of genomics.
  • Nurses can help patients understand how genomics affects disease risk.
  • Ethical nursing care includes understanding the specific ethical considerations related to genomic healthcare (e.g., right not to know).

In which nursing practice settings can genomics be used?

Genomics is used in all practice settings across all aspects of nursing care, including educating patients and families, administering medications, advocating for health promotion and disease prevention and interpreting family histories.

Settings where nurses use or provide genomics-informed care to patients of all ages, families, and communities include but are not limited to:

  • Primary care.
  • Pediatric and adult outpatient clinics.
  • Specialty clinics.
  • Subspecialty clinics.
  • Prenatal and reproductive centers.
  • Inpatient settings.
  • Case management.
  • Community outreach clinics.

How can nurses apply genomics to practice?

Examples of how nurses apply genomics in practice:

  • Record and interpret a comprehensive family history to identify risk for heritable genetic conditions.
  • Understand the genomic basis for certain health conditions and the associated prognosis.
  • Recognize newborn risk for morbidity and mortality based upon identified genetic conditions.
  • Identify risk for asymptomatic individuals with high risk for hereditary cancers.
  • Advocate for interventions based upon individual genetic needs.
  • Facilitate screening and follow up for individuals with known genetic conditions.
  • Encourage genetic testing for at-risk family members.
  • Obtain and verify informed consent.
  • Ensure understanding of all risks, benefits, and limitations for genetic testing and/or research.
  • Use current credible information to answer questions about genomic information or services and assess for understanding.
  • Identify at-risk populations.
  • Form empathetic relationships to support individuals and families at risk for or affected by genetic conditions.
  • Educate individuals, families, and communities about the role of genomics in medication response.
  • Discuss and educate about the function of new genomics-based vaccine.

What ethical, legal, and social implications (ELSI) that are related to genomics, should nurses be aware of?

Nurses’ ethical responsibilities are outlined in the Code of Ethics for Nurses. Parts of this code have a direct connection to genomics.

Self-determination: Patients have both the moral and legal right to control what will be done with and to their bodies. Nurses can talk to patients about benefits, burdens and available options of testing and treatment plans.

Primacy of the patient’s interest: Nurses must understand and protect the uniqueness, worth and dignity of each patient under their care. Each patient must be given the opportunity to play an active role in planning and carrying out care.

Protection of rights of privacy and confidentiality: Privacy is the right to control access to and disclosure or nondisclosure of personal information, including genomic information.

What additional genomics nursing resources are available?

Resources for keeping up to date on genomic advances include websites with detailed repositories of genomic education materials, and email subscriptions.

How are nurses prepared and positioned to provide genomics-informed care?

Nurses practice from a holistic viewpoint. Nurses consider patients, families and communities within their contexts.

  • Genomics must be considered in context, including patients’ genomic information, clinical presentation and the environments in which they live.
  • Nurses consider ethical, legal and social issues for individuals and families.

Nurses have a central position in the healthcare team and interact the most with patients.

  • Nurses are central to interdisciplinary communication and coordination.
  • Nurses translate and relay concerns of patients and family members to the healthcare team.


Nurses have an optimal skillset to apply genomics in all practice settings and roles. Nurses apply genomics principles at the bedside, in the community, in policy and research.

  • Nurses are skilled at obtaining individual and family histories to provide critical information for genomics-informed care.
  • Nurses obtain and analyze data from physical assessments, individual and family histories, laboratory tests and other sources.
  • Nurses plan and implement interventions central to genomics-informed care.
  • Nurses champion patient education and are experts at translating complex topics into lay terms.
  • Nurses are ethical practitioners prepared to advocate for patient needs.


Code of Ethics for Nurses with Interpretive Statements. Silver Spring, MD: American Nurses Association; 2015.

Consensus Panel on Genetic/Genomic Nursing Competencies. Essentials of Genetic and Genomic Nursing: Competencies, Curricula Guidelines, and Outcome Indicators. 2nd ed. Silver Spring, MD: American Nurses Association; 2009.

Greco KE, Tinley S, Seibert D. Essential Genetic and Genomic Competencies for Nurses with Graduate Degrees. Pittsburgh, PA: International Society of Nurses in Genetics (ISONG); 2012.

Informed Decision-Making and Consent Related to Genetic Testing (Clinical and Research): The Role of Nursing. Okemas, MI: International Society of Nurses in Genetics; 2018.

Privacy and Confidentiality of Genetic Information: The Role of the Nurse. Okemas, MI: International Society of Nurses in Genetics; 2018.

Meet the Experts

Sarah Dewell
Sarah Dewell, Ph.D., M.Sc., RN
Assistant Professor ,University of Northern British Columbia

Dr. Sarah Dewell is an assistant professor in the School of Nursing at the University of Northern British Columbia. Her program of research explores the development of precision health through scholarship focused on nursing education, research and practice with a focus on foundational genomic knowledge for all nurses. Prior to becoming a nurse, Dr. Dewell completed a B.Sc. in cell biology and genetics and a master’s in medical genetics at the University of British Columbia. Through her program of research, she combines her interest in genomics with her dedication to advancing nursing education to prepare future nurses for practice in evolving healthcare systems. Additionally, she has an interest in curriculum innovation and evidence-based nursing education. Dr. Dewell is a member of the Inter-Society Coordinating Committee for Practitioner Education in Genomics Nursing Genomics Project group, which is helping nurses in practice learn more about genomics. She is a member of the steering committees for the Global Genomics Nursing Alliance and the Canadian Nursing and Genomics initiative and is also a member of the International Society of Nurses in Genetics.

The Inter-Society Coordinating Committee for Practitioner Education in Genomics (ISCC-PEG) provides a venue for individuals to collaborate and develop educational resources. The opinions expressed in this resource do not reflect the view of all ISCC-PEG members, the National Institutes of Health, the Department of Health and Human Services or the United States government.

Last updated: May 17, 2023