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The National Human Genome Research Institute (NHGRI) offers a one-year residency program in Medical Biochemical Genetics that trains highly motivated physicians to diagnose, manage and counsel patients with metabolic genetic disorders.

Overview

The NHGRI program is unparalleled in several respects. It exposes students to rare genetic disorders that might not be seen in a more typical biochemical genetics program; it is one of the few programs that emphasizes clinical research, and it grants access to the vast resources at the National Institutes of Health (NIH) and at other, highly ranked medical institutions in the national capital area.

The NIH sponsor of the program is the National Human Genome Research Institute. Other participating institutions include Children's Children's National Health System (CNHS), Washington D.C., Kennedy-Krieger Institute, Baltimore, MD and the University of Maryland Medical System, Baltimore, MD.

Eligibility Criteria: Candidates must have an M.D. or D.O. degree and have completed an accredited U.S. residency training program in clinical genetics or an ABMS primary specialty area, be board eligible or board certified in clinical genetics or an ABMS primary specialty area and have a valid, unrestricted U.S. license.

  • Overview

    The NHGRI program is unparalleled in several respects. It exposes students to rare genetic disorders that might not be seen in a more typical biochemical genetics program; it is one of the few programs that emphasizes clinical research, and it grants access to the vast resources at the National Institutes of Health (NIH) and at other, highly ranked medical institutions in the national capital area.

    The NIH sponsor of the program is the National Human Genome Research Institute. Other participating institutions include Children's Children's National Health System (CNHS), Washington D.C., Kennedy-Krieger Institute, Baltimore, MD and the University of Maryland Medical System, Baltimore, MD.

    Eligibility Criteria: Candidates must have an M.D. or D.O. degree and have completed an accredited U.S. residency training program in clinical genetics or an ABMS primary specialty area, be board eligible or board certified in clinical genetics or an ABMS primary specialty area and have a valid, unrestricted U.S. license.

Program Structure

Three months of rotations will be at the NIH, three months at Children's National Health System (CNHS), one month in a biochemical genetics laboratory, two weeks at the Maryland Newborn Screening Laboratory, one month of clinical research at NIH and three and a half months of clinical electives at either NIH, CNHS, University of Maryland specialty clinics, or Kennedy-Krieger Institute.

Although this is a one-year program, most candidates will want to spend 2 to 3 years after the fellowship acquiring skills in the care and clinical research of patients with metabolic disorders. The residency program includes many didactic sessions, courses, seminars, biochemical journal club and metabolic continuity clinic. The course Inborn Errors in Metabolism, a one semester course, is required for all trainees.

Metropolitan Area Genetics Rotations: Children's National Health System (CNHS) : During this rotation, fellows have both inpatient and outpatient responsibilities. They function as genetics consultants for CNHS patients and are involved in the medical management of patients with metabolic disorders. They diagnose, manage and counsel outpatients and participate in the metabolic specialty clinic weekly.

National Institutes of Health (NIH) Clinical Center:  During this rotation, fellows have both inpatient and outpatient responsibilities and are involved in the evaluation and management of patients with various metabolic disorders. Fellows participate in 2 weekly patient care conferences.

Maryland Newborn Screening Laboratory: This rotation will introduce the fellow to the state NBS testing and techniques, as well as many nutritional management protocols for newly diagnosed infants with metabolic disorders. Counseling skills will be improved by teaching referring physicians and parents about positive test results and dietary therapies.

  • Program Structure

    Three months of rotations will be at the NIH, three months at Children's National Health System (CNHS), one month in a biochemical genetics laboratory, two weeks at the Maryland Newborn Screening Laboratory, one month of clinical research at NIH and three and a half months of clinical electives at either NIH, CNHS, University of Maryland specialty clinics, or Kennedy-Krieger Institute.

    Although this is a one-year program, most candidates will want to spend 2 to 3 years after the fellowship acquiring skills in the care and clinical research of patients with metabolic disorders. The residency program includes many didactic sessions, courses, seminars, biochemical journal club and metabolic continuity clinic. The course Inborn Errors in Metabolism, a one semester course, is required for all trainees.

    Metropolitan Area Genetics Rotations: Children's National Health System (CNHS) : During this rotation, fellows have both inpatient and outpatient responsibilities. They function as genetics consultants for CNHS patients and are involved in the medical management of patients with metabolic disorders. They diagnose, manage and counsel outpatients and participate in the metabolic specialty clinic weekly.

    National Institutes of Health (NIH) Clinical Center:  During this rotation, fellows have both inpatient and outpatient responsibilities and are involved in the evaluation and management of patients with various metabolic disorders. Fellows participate in 2 weekly patient care conferences.

    Maryland Newborn Screening Laboratory: This rotation will introduce the fellow to the state NBS testing and techniques, as well as many nutritional management protocols for newly diagnosed infants with metabolic disorders. Counseling skills will be improved by teaching referring physicians and parents about positive test results and dietary therapies.

Faculty and Research Interests

David Adams, M.D. Ph.D.
Oculocutaneous albinism, sialic acid disorders, metabolic diseases

Nicholas Ah Mew, M.D.
Urea cycle disorders, organic acidemias and other disorders of ammonia metabolism

Jessica Albert, Ph.D.
Molecular and biochemical diagnositics

Kimberly Chapman, M.D., Ph.D.
Mitochondrial diseases, metabolic disorders and cardio-genetic diseases

Carlos Ferreira, M.D.
Skeletal dysplasias, inborn errors of metabolism

William A. Gahl, M.D., Ph.D.
Inborn Errors of Metabolism, cystinosis, Hermansky-Pudlak syndrome, Undiagnosed Diseases Program

Fizza Gulamali-Majid, Ph.D.
Director, Maryland Newborn Screening Laboratory

Suzanne Hart, Ph.D.
Molecular and biochemical diagnostics; genetics education

Wendy Introne, M.D.
Alkaptonuria, Chediak-Higashi syndrome

Irini Manoli, M.D., MPH
Organic acidemias, Moebius syndrome

Melissa Merideth, M.D., MPH
Gynecologic aspects of genetic and metabolic diseases

Drew Michael, Ph.D.
Molecular and biochemical diagnostics

Debra Regier, M.D., Ph.D.
Metabolic disorders, genetics education

Oleg Shchelochkov, M.D.
Propionic acidemia

Ellen Sidransky, M.D.
Gaucher disease, Lysosomal storage diseases

Benjamin Solomon, M.D.
Clinical Director, NHGRI

Erin Strovel, Ph.D.
Biochemical diagnostics

Cynthia J. Tifft, M.D., Ph.D.
Glycosphingolipid and glycoprotein disorders includingTay-Sachs and Sandhoff disease, GM1 gangliosidosis, and type 1 sialidosis, undiagnosed diseases program

Charles Venditti, M.D., Ph.D.
Hereditary methylmalonic acidemias and disorders of intracellular cobalamin metabolism

  • Faculty and Research Interests

    David Adams, M.D. Ph.D.
    Oculocutaneous albinism, sialic acid disorders, metabolic diseases

    Nicholas Ah Mew, M.D.
    Urea cycle disorders, organic acidemias and other disorders of ammonia metabolism

    Jessica Albert, Ph.D.
    Molecular and biochemical diagnositics

    Kimberly Chapman, M.D., Ph.D.
    Mitochondrial diseases, metabolic disorders and cardio-genetic diseases

    Carlos Ferreira, M.D.
    Skeletal dysplasias, inborn errors of metabolism

    William A. Gahl, M.D., Ph.D.
    Inborn Errors of Metabolism, cystinosis, Hermansky-Pudlak syndrome, Undiagnosed Diseases Program

    Fizza Gulamali-Majid, Ph.D.
    Director, Maryland Newborn Screening Laboratory

    Suzanne Hart, Ph.D.
    Molecular and biochemical diagnostics; genetics education

    Wendy Introne, M.D.
    Alkaptonuria, Chediak-Higashi syndrome

    Irini Manoli, M.D., MPH
    Organic acidemias, Moebius syndrome

    Melissa Merideth, M.D., MPH
    Gynecologic aspects of genetic and metabolic diseases

    Drew Michael, Ph.D.
    Molecular and biochemical diagnostics

    Debra Regier, M.D., Ph.D.
    Metabolic disorders, genetics education

    Oleg Shchelochkov, M.D.
    Propionic acidemia

    Ellen Sidransky, M.D.
    Gaucher disease, Lysosomal storage diseases

    Benjamin Solomon, M.D.
    Clinical Director, NHGRI

    Erin Strovel, Ph.D.
    Biochemical diagnostics

    Cynthia J. Tifft, M.D., Ph.D.
    Glycosphingolipid and glycoprotein disorders includingTay-Sachs and Sandhoff disease, GM1 gangliosidosis, and type 1 sialidosis, undiagnosed diseases program

    Charles Venditti, M.D., Ph.D.
    Hereditary methylmalonic acidemias and disorders of intracellular cobalamin metabolism

How to Apply

Apply to this program through the NIH Graduate Medical Education Application System . Candidates must have an M.D. degree and have completed an ACGME accredited U.S. residency training program in clinical genetics, be board eligible or board certified in clinical genetics and have a valid, unrestricted U.S. license.

Learn more about Graduate Medical Education at the NIH.

Program Contacts

Melissa Merideth, M.D., M.P.H., FACMG, FACOG
Program Director, Medical Biochemical and Clinical Biochemical Genetics Fellowships
Interim Program Director, Laboratory Genetics and Genomics Fellowship
National Human Genome Research Institute,
National Institutes of Health
10 Center Drive - MSC 1851
Building 10, Room 10C-103
Bethesda, Maryland 20892-1851

Phone: 301-402-1816
Fax: 301-480-2435
E-mail: 
mmeridet@mail.nih.gov

Donald Hadley, M.S., C.G.C
Deputy Program Director & Coordinator
Medical Biochemical Genetics Fellowship
National Human Genome Research Institute
National Institutes of Health
35 Convent Drive
Building 35, Room 1B205
Bethesda, Maryland 20892

Phone: 301-496-3980
Fax: 301-496-7157
E-mail: dhadley@mail.nih.gov

  • Program Contacts

    Melissa Merideth, M.D., M.P.H., FACMG, FACOG
    Program Director, Medical Biochemical and Clinical Biochemical Genetics Fellowships
    Interim Program Director, Laboratory Genetics and Genomics Fellowship
    National Human Genome Research Institute,
    National Institutes of Health
    10 Center Drive - MSC 1851
    Building 10, Room 10C-103
    Bethesda, Maryland 20892-1851

    Phone: 301-402-1816
    Fax: 301-480-2435
    E-mail: 
    mmeridet@mail.nih.gov

    Donald Hadley, M.S., C.G.C
    Deputy Program Director & Coordinator
    Medical Biochemical Genetics Fellowship
    National Human Genome Research Institute
    National Institutes of Health
    35 Convent Drive
    Building 35, Room 1B205
    Bethesda, Maryland 20892

    Phone: 301-496-3980
    Fax: 301-496-7157
    E-mail: dhadley@mail.nih.gov

Last updated: March 30, 2020